Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
WHO Collaborating Centres (Page)
https://www.swisstph.ch/fr/research/who-collaborating-centres
for Modelling, Monitoring and Training for Malaria Control and Elimination The purpose of the Collaboration Centre is to provide technical advice, improve malaria prevention modelling methods, evaluate routine [...] Diseases and Programmes Unit. The WHO Collaborating Centre for Modelling, Monitoring and Training for Malaria Control and Elimination is based in the Health Interventions Unit. The WHO Collaborating Centre for
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Mathematical Epidemiology (Page)
https://www.swisstph.ch/fr/about/eph/disease-modelling/mathematical-epidemiology
Correction: Testing and treatment for malaria elimination: a systematic review. Malar J . 2024;23:63. DOI: 10.1186/s12936-024-04861-x Related Topics Health Interventions Malaria Helminths Human African Trypanosomiasis [...] computational models to improve understanding of population, infection and disease dynamics, focusing on malaria and neglected tropical diseases. Nakul Chitnis PhD, PD Dr. Group Leader +41612848242 nakul.chitn [...] Hofer Lars Kamber Alexis Martin Louis Perriens Taru Singhal...
Molecular Immunology | Research at Swiss TPH (Page)
https://www.swisstph.ch/fr/about/med/molecular-immunology
vaccine development. Malaria P. falciparum: Developing a Synthetic Subunit Candidate Vaccine Malaria is one of the most serious infectious diseases of humans. New approaches to combat malaria are urgently needed [...] efficacy of therapeutic interventions. This research focuses primarily on three infectious diseases: malaria due to Plasmodium falciparum, bacterial meningitis caused by Neisseria meningitides and Streptococcus [...] developing synthetic peptide structures that induce...
Drug Discovery Work (Page)
https://www.swisstph.ch/fr/about/mpi/parasite-chemotherapy/drug-discovery-work
evaluation of new compounds. The Medicines for Malaria Venture (MMV) Foundation supports the project ‘Syntheticperoxides’ and the new projects ‘Oral diamidines for malaria’. With a master contract with the MMV [...] Drug Discovery Work Tropical parasitic diseases, as malaria, African sleeping sickness, Chagas disease or Leishmaniasis represent still a large health risk for a majority of the worlds population. These [...] trematodes. Links WHO/TDR European COST B22 Drugs for Neglected Diseases...