Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
Urban agriculture and <em>Anopheles</em> habitats in Dar es Salaam, Tanzania (Publications)
than a fifth of all breeding sites of malaria vectors in Dar es Salaam. It is suggested that strategies comprising an integrated malaria control effort in malaria-endemic African cities include participatory
Population pharmacokinetics of the antimalarial amodiaquine: a pooled analysis to optimize dosing (Publications)
Amodiaquine plus artesunate is the recommended antimalarial treatment in many malaria-endemic countries. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled [...] amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over three days. Plasma [...] 22.4% (15.6 - 31.9%) lower at the start of treatment than during convalescence,...
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify or...
Comparative study of the effects of artemether and artesunate on juvenile and adult<em> Schistosoma mansoni</em> in experimentally infected mice (Publications)
stages of schistosome parasites. Since artemisinin derivatives will be increasingly used to treat malaria, it is important to study the effects of 7-day monotherapy regimens on schistosome infections. We [...] artemether or artesunate at various doses and regimens including those currently used for monotherapy of malaria. Three doses of artemether, at concentrations of 150 or 300 mg/kg, administered to mice with juvenile [...] discussions on the effect and use of artemisinin derivatives against...
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Infection Biology and Molecular Epidemiology | Swiss TPH (Page)
https://www.swisstph.ch/fr/infection-biology-and-molecular-epidemiology
infectious diseases. In the field of the life sciences, Swiss TPH places particular emphasis on malaria, tuberculosis and other poverty-related infectious diseases. We utilise state-of-the-art basic research [...] of new drugs, diagnostics and vaccines. Helminths HIV/AIDS Human African Trypanosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and <em>in vivo</em> efficacy in the... (Publications)
SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During [...] Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rgamma(null) (NSG)
