Case studies in public-private-partnership in health with the focus of enhancing the accessibility of health interventions (Publications)
level NGO consortium with a focus on malaria and the second one is an international advocacy group with an overarching goal of protecting children against malaria through an innovative mechanism. The case [...] case study approach is used to analyze why the PPP approach was used to address malaria control and how it was implemented. Both PPPs demonstrated that relationships between the public and private sector
The influence of zinc supplementation on morbidity due to <em>Plasmodium falciparum</em>: a randomized trial in preschool children in Papua New Guinea (Publications)
determine the influence of zinc on malaria morbidity we conducted a randomized placebo-controlled trial of daily zinc supplementation in children residing in a malaria endemic region of Papua New Guinea [...] mg elemental zinc (n = 136) or placebo (n = 138) for 6 days a week for 46 weeks. Slide-confirmed malaria episodes were detected by surveillance of cases self-reporting to a local health center. Cross-sectional
Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying (Publications)
cross-sectional survey data collected from three historical trials of indoor residual spraying against malaria: one from two contiguous districts in Tanzania-Kenya (Pare Taveta) carried out in 1954, the others [...] showed considerable variation but no general age trend. There was also no clear relationship between malaria endemicity and infection duration. Analyses of successive sampling from the same individuals with [...] areas. Periods of several years may be required to evaluate long-term...
The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue (Publications)
cavity of the enzyme. Like MB, also PYO was also found to be active against blood schizonts of the malaria parasite P. falciparum in vitro. Furthermore, both compounds were active against the disease transmitting [...] PYO, is well tolerated and represents a promising agent for MB-based combination therapies against malaria. Current and future clinical studies can be guided by the comparisons between MB and PYO reported [...] reported here. Additionally, it is of interest to study if and to what...
Clonal expansion of artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda is associated with substandard treatment practices (Publications)
the frame of the Community Access to Rectal Artesunate for Malaria project, blood samples were collected from children with signs of severe malaria before and after RAS implementation. K13 polymorphisms were [...] a driver of this recent emergence. Rectal artesunate (RAS) as pre-referral treatment for severe malaria in children was implemented in 2019 in Northern Uganda. The objective of this study was to determine
High proportions of asymptomatic and submicroscopic <em>Plasmodium vivax </em>infections in a peri-urban area of low transmission in the Brazilian... (Publications)
regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. [...] conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were [...] carried gametocytes and presented low asexual parasitemia. This reservoir actively...
Evaluation of anopheline diversity and abundance across outdoor collection schemes utilizing cdc light traps in Nchelenge District, Zambia (Publications)
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and [...] may be exposed to outdoors. Nchelenge District in northern Zambia experiences persistently high malaria transmission even with ITNs and IRS in place. However, very few studies have examined outdoor vector [...] including a number of infectious An. funestus, may partially explain the...
Infectious Diseases | Swiss TPH (Page)
https://www.swisstph.ch/fr/topics/infectious-diseases
African Tryponosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis Swiss TPH has a longstanding experience in research into poverty-related diseases such as malaria, tuberculosis or HIV/AIDS
Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms [...] imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 7. Dynamics of multiple <em>Plasmodium falciparum </em>infections in infants... (Publications)
The force of infection and recovery rate for malaria in infants in a highly endemic area of Tanzania were analysed using polymerase chain reaction-restriction fragment length polymorphism genotyping of [...] recovery rates were in children under 4 months of age. The higher susceptibility of infants to clinical malaria in comparison with older children, in areas of very high transmission, may be largely a consequence