Medicines Development | Research at Swiss TPH (Page)
https://www.swisstph.ch/fr/about/med/medicines-development
platforms, malaria drug resistance genotyping services and the development of vaccines and treatments for tropical infectious diseases. The MDU excels in providing global genotyping services for malaria resistance [...] on diseases such as malaria, respiratory viruses, Buruli ulcer and undifferentiated febrile diseases. Our Core Competencies Our core expertise is in molecular genotyping for malaria drug resistance testing [...] testing, diagnostic development of non-invasive and innovative...
Expert Committee Memberships | Scientific and Policy Advice (Page)
https://www.swisstph.ch/fr/about/memberships
Partnership to End Malaria (Coordinator) Multi Sectoral Action Working Group, RBM Partnership to End Malaria (Coordinator) Vector Control Working Group, RBM Partnership to End Malaria (Coordinator) Christian [...] Institute of Medical Research (BC) Fakultätsversammlung Phil Nat Uni Basel WHO Malaria Policy Advisory Committee (MPAG) Zanzibar Malaria Elimination Advisory Committee Jennifer Keiser WHO Advisory Group on So [...] international organisations such as the WHO on evidence-based health...
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
isolates and lab-raised drug-resistant strains of Pf. It was efficacious in the humanized NSG mouse malaria infection model at a single oral dose of 32 mg/kg. This compound was nonteratogenic in the zebrafish [...] human dose, indicating that this series has the potential to deliver a preclinical candidate for malaria.
Fast-killing tyrosine amide ((<em>S</em>)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance... (Publications)
Current malaria treatments are threatened by drug resistance, and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with [...] fast-killing mechanism of action, available for lead optimization to generate new treatments for malaria.
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
Case studies from the biomedical and health systems research activities of the Swiss Tropical Institute in Africa (Publications)
Institute. Schistosomiasis and malaria control provide the background to problems related to the efficacy of tools. In particular, information on the trial of a malaria vaccine candidate (SPf66) is given