Fast-killing tyrosine amide ((<em>S</em>)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance... (Publications)
Current malaria treatments are threatened by drug resistance, and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with [...] fast-killing mechanism of action, available for lead optimization to generate new treatments for malaria.
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual
Case studies from the biomedical and health systems research activities of the Swiss Tropical Institute in Africa (Publications)
Institute. Schistosomiasis and malaria control provide the background to problems related to the efficacy of tools. In particular, information on the trial of a malaria vaccine candidate (SPf66) is given
Addressing the intracellular vestibule of the plasmodial lactate transporter PfFNT by p-substituted inhibitors amplifies <em>in vitro</em> activity (Publications)
Inhibition of the lactate transporter PfFNT is a valid novel mode of action against malaria parasites. Current pyridine-substituted pentafluoro-3-hydroxy-pent-2-en-1-ones act as substrate analogs with [...] metabolized, the more stable p-acetanilide cleared 99.7% of parasites at 4 × 50 mg kg(-1) in a mouse malaria model. Future stabilization of the p-substitution against metabolism may translate the gain in in
Fast-killing tyrosine amide ((<em>S</em>)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance... (Publications)
Current malaria treatments are threatened by drug resistance, and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with [...] fast-killing mechanism of action, available for lead optimization to generate new treatments for malaria.
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
isolates and lab-raised drug-resistant strains of Pf. It was efficacious in the humanized NSG mouse malaria infection model at a single oral dose of 32 mg/kg. This compound was nonteratogenic in the zebrafish [...] human dose, indicating that this series has the potential to deliver a preclinical candidate for malaria.
Basic Research in Infection Biology | Swiss TPH (Page)
https://www.swisstph.ch/fr/research/basic-research-in-infection-biology
are neglected tropical diseases that affect the poorest communities. Malaria A gametocyte - the sexual form of Plasmodium Malaria is caused by unicellular parasites of the genus Plasmodium , which are [...] Infection Biology conduct cutting-edge basic research on infectious diseases of poverty, including Malaria (caused by Plasmodium spp .) Tuberculosis (caused by Mycobacterium tuberculosis ) Buruli ulcer (caused [...] Mycobacterium ulcerans ) Sleeping sickness/African trypanosomiasis (caused...
