Long-term trends in <em>Anopheles gambiae</em> insecticide resistance in Côte d'Ivoire (Publications)
for ITNs. The rapid rise in insecticide resistance in African malaria vectors has raised alarms about the sustainability of existing malaria control activities. This problem might be particularly acute [...] BackgroundMalaria control is heavily dependent on the use of insecticides that target adult mosquito vectors via insecticide treated nets (ITNs) or indoor residual spraying (IRS). Four classes of insecticide
Local concepts of anemia-related illnesses and public health implications in the Taabo health demographic surveillance system, Côte d'Ivoire (Publications)
newly recruited ones. Malaria und nutritional issues as understood and managed by the population differed from definitions and recommendations provided by the health system. Malaria was not acknowledged [...] which in turn might affect their health status. Local terminology and beliefs about anemia and malaria should be carefully considered when developing health intervention and education programs. The similarity
Comparison of detection methods to estimate asexual <em>Plasmodium falciparum</em> parasite prevalence and gametocyte carriage in a community survey... (Publications)
BACKGROUND: The use of molecular techniques to detect malaria parasites has been advocated to improve the accuracy of parasite prevalence estimates, especially in moderate to low endemic settings. Molecular [...] carefully evaluated. Light microscopy (LM) and rapid diagnostic tests (RDT) are commonly used to detect malaria infection in resource constrained areas, but their limited sensitivity results in underestimation [...] identified by PCR. Thus, LM is not a sufficiently accurate technique...
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
BACKGROUND: Many individuals at risk of malaria also have micronutrient deficiencies that may hamper protective immunity. Vitamin A is central to normal immune function, and supplementation has been shown [...] morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity. METHODS: This randomised double-blind placebo-controlled trial of vitamin A supplementation [...] randomly assigned high-dose vitamin A (n=239) or placebo (n=241), every 3...
Long-term acceptability, durability and bio-efficacy of ZeroVector® durable lining for vector control in Papua New Guinea (Publications)
had previously been installed in 40 homes across four study sites representing a cross section of malaria transmission risk and housing style. Structured questionnaires, DL visual inspections and group [...] at 36-months post-installation, the material and fixtures proved durable and the efficacy against malaria vectors did not decrease. However, the DL material had been removed from over 50% of the original [...] suggest DL may not be an appropriate vector control method for large-scale use in...
Resistance of <em>Anopheles stephensi</em> to selected insecticides used for indoor residual spraying and long-lasting insecticidal nets in Ethiopia (Publications)
BACKGROUND: Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of invasive Anopheles stephensi, capable of transmitting Plasmodium [...] 2016. The ecology of this mosquito species differs from that of Anopheles arabiensis, the primary malaria vector in Ethiopia. This study aimed to evaluate the efficacy of selected insecticides, which are [...] are used in indoor residual spraying (IRS) and selected long-lasting...
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle (Publications)
Quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with antimalarial [...] findings indicate that metal coordination is a potential chemical tool for drug design and discovery in malaria.
A community-randomised evaluation of the effect of IPTi on anti-malarial drug resistance in southern Tanzania (Publications)
is the administration of sulphadoxine-pyrimethamine (SP) at 2, 3 and 9 months of age to prevent malaria. We investigated the influence of IPTi on drug resistance.Methods. Twenty-four areas were randomized [...] did not increase drug pressure, or the selection on dhfr and dhps mutants, when SP was first line malaria treatment. Introduction of artemether-lumefantrine was followed by an increase in dhfr mutations