Prevalence and determinants of undernutrition in schoolchildren in the Kilombero district, south-eastern Tanzania (Publications)
wasting, and underweight, while logistic regression analyses examined sociodemographic background, malaria infection, anaemia, anthropometric measures, and dietary diversity score as potential factors. The [...] obesity was 11.8%, 4.3%, 3.9%, 11.1%, and 2.0%, respectively. Overall, 1.5% of the children had malaria, as determined by rapid diagnostic tests, and 0.4% had severe anaemia. Univariate analysis indicated
Acceptability and use of insecticide impregnated bednets in northern Ghana (Publications)
washing soaps could improve protection for young children. The success of the promotion of IIBNs in malaria control programmes will depend on the cost of the package and the time of year that it is delivered [...] the intervention in this study, and it should be included as an important component of national malaria control programmes.
Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household... (Publications)
(danger signs) in rural communities are crucial for preventing complications and death from severe malaria, pneumonia, and diarrhea. We set out to determine the treatment-seeking practices and treatment patterns [...] of age with an acute febrile illness, with or without danger signs of severe disease, in a highly malaria-endemic area of northern Uganda. Three household surveys were conducted from November through December
New <em>in vitro</em> interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations (Publications)
The development and spread of drug-resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require [...] will significantly improve and streamline the economic development of new drug combinations for malaria and potentially also in other therapeutic areas.
Changes in metabolic phenotypes of <em>Plasmodium falciparum</em> <em>in vitro</em> cultures during gametocyte development (Publications)
s are the Plasmodium life stage that is solely responsible for malaria transmission. Despite their important role in perpetuating malaria, gametocyte differentiation and development is poorly understood
Parasite-host dynamics throughout antimalarial drug development stages complicate the translation of parasite clearance (Publications)
Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes pre-clinical murine and experimental human malaria infection studies to evaluate
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Clinical Trials at Swiss TPH | Bringing Science to Patients (Page)
https://www.swisstph.ch/fr/services/clinical-trials
Trial for New Malaria Vaccine Malaria persists as a significant challenge in tropical and subtropical regions, prompting the initiation of the SumayaVac-1 study—a clinical trial for a new malaria vaccine known [...] and neonates weighing less than 5kg with acute malaria. The CALINA study is led by Novartis, with the scientific and financial support of Medicines for Malaria Venture (MMV), and is part of the PAMAfrica [...] capacity strengthening activities in public health and malaria, and...
Synthesis of novel diazabicycles and their antiprotozoal activities (Publications)
potencies against Plasmodium falciparum K-1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness