Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as the [...] azines demonstrate potent preventive, therapeutic, and transmission-blocking activity in rodent malaria models, are active against blood-stage field isolates of the major human pathogens P. falciparum [...] to identify drugs with an ideal activity profile for the prevention, treatment and...
A molecular marker of artemisinin-resistant <em>Plasmodium falciparum</em> malaria (Publications)
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular
Child mortality patterns in rural Tanzania: an observational study on the impact of malaria control interventions (Publications)
BACKGROUND: Between 1997 and 2009, a number of key malaria control interventions were implemented in the Kilombero and Ulanga Districts in south central Tanzania to increase insecticide-treated nets (ITN) [...] (ITN) coverage and improve access to effective malaria treatment. In this study we estimated the contribution of these interventions to observed decreases in child mortality. METHODS: The local Health and [...] security. We used Poisson regression with linear and segmented effects to...
Assessing the relationship between environmental factors and malaria vector breeding sites in Swaziland using multi-scale remotely sensed data (Publications)
Many entomological studies have analyzed remotely sensed data to assess the relationship between malaria vector distribution and the associated environmental factors. However, the high cost of remotely