Estimation of the antirelapse efficacy of tafenoquine, using <em>Plasmodium vivax</em> genotyping (Publications)
Plasmodium vivax relapse prevention is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled Phase IIb study in Peru, India, Thailand
Causes of fever in returning travelers: a European multicenter prospective cohort study (Publications)
diagnostic algorithm was used ensuring a systematic evaluation of all participants. After ruling out malaria, PCRs and serologies for dengue, chikungunya and Zika viruses were performed in all patients presenting
Diseases and Programmes | Swiss TPH (Page)
https://www.swisstph.ch/fr/about/scih/diseases-and-programmes
(ESHIA) in Burkina Faso on the use of genetically modified mosquitoes (GMMs) for future malaria control. Target Malaria - a vector control research collaborative based at Imperial College, London - aims to [...] evaluations; and (iii) poverty-related diseases such as Neglected Tropical Diseases, tuberculosis and malaria. From validation to application and health impact assessment We pay particular attention to “access” [...] to develop genetic technologies to modify mosquitoes to ultimately...
Vector Research and Control (Page)
https://www.swisstph.ch/fr/about/eph/vector-biology/vector-research-and-control
Arch Tierheilkd . 2023;165(5):321-331. DOI: 10.17236/sat00395 Related Topics Malaria More to Explore Dynamical Modelling Malaria Initiative Related Activities Preclinical Research Arthropod Testing Facility [...] particularly important vectors as they spread some of the most devastating infectious diseases such as malaria, dengue fever, West Nile fever or Zika virus infections. Investigation of Vectors and Development [...] Study of a Self-Limiting Nondrive Strain of Genetically Modified...
Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies (Publications)
were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested