Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery (Publications)
accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasis Boxes. Here, we screened the Pathogen Box
Adherence to standard treatment guidelines among prescribers in primary healthcare facilities in the Dodoma region of Tanzania (Publications)
in 2872 cases. The nine most prevalent conditions were upper respiratory tract infections (25%), malaria (18%), diarrhoea (9.9%), pneumonia (6.1%), skin problems (5.8%), gastrointestinal diagnoses (5%) [...] of cases that did not adhere to STG was highest with patients with skin problems and lowest for malaria. Conclusion: Prescribers' general adherence to national STG in primary HCF in the public sector in
Co-infection of the four major <em>Plasmodium </em>species: effects on densities and gametocyte carriage (Publications)
BACKGROUND: Co-infection of the four major species of human malaria parasite Plasmodium falciparum (Pf), P. vivax (Pv), P. malariae (Pm), and P. ovale sp. (Po) is regularly observed, but there is limited [...] (95% CI: 0.95, 1.79) for gametocytes. This excess co-infection risk was partially attributable to malaria infections clustering in some villages. Pf-Pv-Pm triple infections were four times more frequent
Peri-domestic vector control interventions using attractive targeted sugar baits and push-pull strategies (Publications)
Great challenges to sustained malaria and arbovirus control remain, including transmission by vectors that occur outdoors or outside of sleeping hours, the enormous scale of larval breeding in urban centres [...] finding could potentially be due to the size of these studies, because community-level protection from malaria using removal trapping has been demonstrated.
Expansion of artemisinin partial resistance mutations and lack of histidine rich protein-2 and -3 deletions in <em>Plasmodium falciparum</em>... (Publications)
BACKGROUND: Emerging artemisinin partial resistance and diagnostic resistance are a threat to malaria control in Africa. Plasmodium falciparum kelch13 (k13) propeller-domain mutations that confer artemisinin [...] provide early detection of partner drug resistance, which would likely compromise control and increase malaria morbidity and mortality in East Africa.
Attributes of <em>Anopheles gambiae</em> swarms in South Central Uganda (Publications)
BACKGROUND: Anopheles gambiae continues to be widespread and an important malaria vector species complex in Uganda. New approaches to malaria vector control are being explored including population suppression
Sub-lethal exposure to chlorfenapyr reduces the probability of developing <em>Plasmodium falciparum</em> parasites in surviving Anopheles mosquitoes (Publications)
BACKGROUND: Pyrethroid resistance in the key malaria vectors threatens the success of pyrethroid-treated nets. To overcome pyrethroid resistance, Interceptor(®) G2 (IG2), a 'first-in-class' dual insecticidal [...] the intensity of the P. falciparum infection. This will likely also contribute to the reduction of malaria in communities beyond the direct killing of mosquitoes.
Multi-country evaluation of the durability of pyrethroid plus piperonyl-butoxide insecticide-treated nets: study protocol (Publications)
distributions of long-lasting insecticidal nets (LLINs) have contributed to large reductions in the malaria burden. However, this success is in jeopardy due in part to the increasing pyrethroid-resistant mosquito [...] containing pyrethroid and piperonyl-butoxide (PBO) have shown a greater reduction in the incidence of malaria than pyrethroid LLINs in areas with pyrethroid-resistant mosquitoes. However, the durability (attrition
Operational challenges to continuous LLIN distribution: a qualitative rapid assessment in four countries (Publications)
BACKGROUND: The World Health Organization recommends that long-lasting insecticidal nets (LLINs) for malaria prevention should be distributed continuously through antenatal care (ANC) and the expanded programme [...] participants were included (23 in Kenya, 13 in Malawi, 18 in Mali and 16 in Rwanda), drawn from malaria programmes, ANC and EPI programmes, government logistics units, and partner organizations. Interviews
Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya (Publications)
anti-malarial mono-therapies, malaria endemic countries in Africa now use artemisinin-based combination therapy (ACT) as recommended first-line treatment for uncomplicated malaria. Patients' adherence to ACT