Detection of pathogens of acute febrile illness using polymerase chain reaction from dried blood spots (Publications)
1% specificity against the whole blood qPCR cutoff of 21 that has been previously suggested for malaria diagnosis. For other pathogens investigated, DBS testing yielded a sensitivity of only 8.5% but a
Additional blood meals increase sporozoite infection in <em>Anopheles</em> mosquitoes but not <em>Plasmodium falciparum</em> genetic diversity (Publications)
multiple blood meals on the number of P. falciparum genotypes developing from polyclonal natural human malaria infections (field-isolates) remains unexplored. Here, we experimentally infect An. gambiae with P
Pyrethroid and etofenprox resistance in <em>Anopheles gambiae </em>and <em>Anopheles coluzzii </em>from vegetable farms in Yaounde, Cameroon:... (Publications)
Previous studies have indicated widespread insecticide resistance in malaria vector populations from Cameroon. However, the intensity of this resistance and underlying mechanisms are poorly known. Therefore
The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes (Publications)
vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE-formulated peptide was
Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439 (Publications)
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS
Differential infectivity of Plasmodium for mosquitoes (Publications)
The four human malarias - Plasmodium falciparum, P. vivax, P. ovale and P. malariaecan - canonly be transmitted by mosquitoes of the genus Anopheles, although not all species (nor all strains) of these
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate... (Publications)
DHODH inhibitors have great potential for use in prophylaxis, which represents an unmet need in the malaria drug discovery portfolio for endemic countries, particularly in areas of high transmission in Africa
Summer Symposium 2018 (Page)
https://www.swisstph.ch/fr/about/events/summer-symposium-2018
Clinical Research Worlds – Approaches and Challenges Moderator: Wiweka Kaszubska, Medicines for Malaria Venture, Geneva, Switzerland 11:15 The Big Pharma Approach and Future Developments, Anthony Man, [...] Clinical Practice, Brussels, Belgium 14:00 Working in a PDP Business Model, David Reddy, Medicines for Malaria Venture, Geneva, Switzerland 14:30 The Future of Drug Development, Djordje Filipovic, Novartis I
Bioactives (Page)
https://www.swisstph.ch/fr/services/bioactives
collaboration with Swiss TPH include novel treatments for Buruli ulcer, human African trypanosomiasis, malaria and soil-transmitted helminths. Available Drug Efficacy Tests According to Pathogen Species Bacteria [...] mansoni T. b. rhodesiense between red blood cells Aedes aegypti Related Topics Infectious Diseases Malaria Helminths Human African Trypanosomiasis (HAT) Tuberculosis Related Activities Arthropod Testing Facility
Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of