School distribution as keep-up strategy to maintain universal coverage of long-lasting insecticidal nets: implementation and results of a program in... (Publications)
LLIN ownership and use is expected to have increased, potentially further reducing the burden of malaria in the Southern Zone of Tanzania.
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in <em>Plasmodium... (Publications)
artemisinin-based combination therapy (ACT) recommended as first-line treatment of Plasmodium falciparum malaria in disease-endemic countries. Studies by Eckstein-Ludwig and co-workers showed both thapsigargin
Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in <em>Anopheles arabiensis</em> sampled from an... (Publications)
compromise the use of insecticides for the control of vector-borne diseases. The tolerance of the malaria vector, Anopheles arabiensis to deltamethrin was determined in a field population from a cotton-growing
Novel inhibitors of <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase with anti-malarial activity in the mouse model (Publications)
Plasmodium falciparum, the causative agent of the most deadly form of human malaria, is unable to salvage pyrimidines and must rely on de novo biosynthesis for survival. Dihydroorotate dehydrogenase (DHODH)
Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified
Morbidity due to <em>Schistosoma mansoni</em>: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with... (Publications)
chronically evolved morbidity and/or that other interacting factors were involved, e.g. malnutrition and malaria. At 1-year follow-up, ACR scores showed an overall trend of regression towards the mean, potentially
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
the toolbox for drug discovery for protozoal diseases such as human African trypanosomiasis and malaria. The method could probably be adapted to other protozoan parasites, especially those growing ext
Cyclic nucleotide-specific phosphodiesterases of <em>Plasmodium falciparum</em>: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral... (Publications)
potential targets for PDE inhibitor-based anti-parasitic drugs. Genomes of the various agents of human malaria, most notably Plasmodium falciparum, all contain four genes for class 1 PDEs. The catalytic domains
School distribution as keep-up strategy to maintain universal coverage of long-lasting insecticidal nets: implementation and results of a program in... (Publications)
LLIN ownership and use is expected to have increased, potentially further reducing the burden of malaria in the Southern Zone of Tanzania.
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals (Publications)
such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using