Imported strongyloidosis: a longitudinal analysis of 31 cases (Publications)
BACKGROUND: Attention regarding imported tropical diseases is typically focused on malaria, although other parasitic diseases such as strongyloidosis may also cause serious health problems. The importance
Antiprotozoal activity of <em>Buxus sempervirens</em> and activity-guided isolation of <em>O</em>-tigloylcyclovirobuxeine-B as the main constituent... (Publications)
Buxus sempervirens L. (European Box, Buxaceae) has been used in ethnomedicine to treat malaria. In the course of our screening of plant extracts for antiprotozoal activity, a CH2Cl2 extract from leaves
Amplicon deep sequencing improves <em>Plasmodium falciparum</em> genotyping in clinical trials of antimalarial drugs (Publications)
Clinical trials monitoring malaria drug resistance require genotyping of recurrent Plasmodium falciparum parasites to distinguish between treatment failure and new infection occurring during the trial
Different classes of genomic inserts contribute to human antibody diversity (Publications)
elements from distant genes in antibody transcripts. Independent of the preexposure of donors to malaria parasites, non-VDJ inserts were detected in 80% of individuals at frequencies of 1 in 10(4) to 10(5)
Drug repurposing in the chemotherapy of infectious diseases (Publications)
attack that are divergent share common ancestry (e.g., prokaryotic targets in the apicoplast of malaria parasites), whereas those that are convergent arise from a shared lifestyle (e.g., the susceptibility
The cost-effectiveness of permethrin impregnated bednets in preventing child mortality in Kassena-Nankana district of Northern Ghana (Publications)
bednets are now being widely promoted as an effective means of protecting African children against malaria, but there is little evidence of their cost-effectiveness. The impact on child mortality of introducing
Design, synthesis and evaluation of praziquantel analogues and new molecular hybrids as potential antimalarial and anti-schistosomal agents (Publications)
Malaria and schistosomiasis are two of the neglected tropical diseases that persistently wreak havoc worldwide. Although many antimalarial drugs such as chloroquine are readily available, the emergence
Genetic validation of <em>Pf</em>FKBP35 as an antimalarial drug target (Publications)
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative
7-<em>N</em>-substituted-3-oxadiazole quinolones with potent antimalarial activity target the cytochrome <em>bc</em>1 complex (Publications)
parasite and male gamete development and reduced asexual parasitemia in a P. berghei mouse model of malaria. Correcting the limited aqueous solubility and the high susceptibility to cyt b Q(o) site resistant
2-Octadecynoic acid as a dual life stage inhibitor of <em>Plasmodium</em> infections and plasmodial FAS-II enzymes (Publications)
The malaria parasite Plasmodium goes through two life stages in the human host, a non-symptomatic liver stage (LS) followed by a blood stage with all clinical manifestation of the disease. In this study