Selection and reversal of <em>Plasmodium berghei</em> resistance in the mouse model following repeated high doses of artemether (Publications)
Artemether, a derivative of artemisinin, is effectively used for the treatment of malaria without any clinically relevant resistance to date. Artemether has also been developed as an antischistosomal agent
Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of beta-hematin formation (Publications)
identification of novel scaffolds for the development of effective and safe treatments to fight malaria is urgently needed. One of the main opportunities is the discovery of new molecules from natural
<em>Plasmodium falciparum Plasmodium</em> helical interspersed subtelomeric proteins contribute to cytoadherence and anchor <em>P. falciparum</em>... (Publications)
endothelium is conferred through the parasite-derived virulence factor PfEMP1, the major contributor to malaria severity. PfEMP1 located at knob structures on the erythrocyte surface is anchored to the cytoskeleton
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Phase
MAHRP2, an exported protein of <em>Plasmodium falciparum</em>, is an essential component of Maurer's cleft tethers (Publications)
Summary Upon invasion into erythrocytes, the malaria parasite Plasmodium falciparum must refurbish the host cell. The objective of this study was to elucidate the location and function of MAHRP2 in these
<em>Schistosoma</em>, other helminth infections, and associated risk factors in preschool-aged children in urban Tanzania (Publications)
and performed medical examinations. We performed full blood cell counts and screened for HIV and malaria. Point-of-care circulating cathodic antigen (POC-CCA), urine filtration, Kato-Katz, FLOTAC, and Baermann
<em>Plasmodium vivax </em>molecular diagnostics in community surveys: pitfalls and solutions (Publications)
ial DNA-based assay increased prevalence from 4.9 to 6.5%. The usefulness of molecular tests in malaria epidemiological studies is widely recognized, especially when precise prevalence rates are desired
Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em> (Publications)
asexual intraerythrocytic development of Plasmodium falciparum, causing the most severe form of human malaria, is marked by extensive host cell remodeling. Throughout the processes of invasion, intracellular
<em>In vitro</em> antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from <em>Pappea capensi</em>s EckI &... (Publications)
The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms. AIM OF STUDY: The main aim of this study was to evaluate the antiplasmodial [...] in P. capensis twigs. CONCLUSION: The study validates the ethnomedicinal use of P. capensis for malaria treatment. It demonstrated the potential of discovering novel antiplasmodial constituents that could
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new insights and discuss solutions to pressing health challenges. Upcoming Events 12-13 June 2025: Malaria in Focus 28 August 2025: Beat the Heat Conference 11 September 2025: Integrated People-Centred Care [...] Location: Swiss TPH, Seminar Room 6 & online Event category: Partner Event 12.06.2025 - 13.06.2025 Malaria in Focus: From Research to Global Action Location: Swiss TPH, Seminar Room 4 Event category: Swiss
