The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression [...] maintenance. In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members
Evaluation of different deployment strategies for larviciding to control malaria: a simulation study (Publications)
METHODS: A malaria transmission model, OpenMalaria, was used to simulate varying larviciding strategies and their impact on host-seeking mosquito densities, entomological inoculation rate (EIR) and malaria prevalence [...] BACKGROUND: Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary [...] g were simulated for three transmission intensities and four...
New methodological approaches to monitor long lasting insecticidal nets (LLINs) durability for sustained malaria control (Publications)
Long lasting insecticidal nets (LLINs) are the current primary vector control measure to prevent malaria transmission. They function by inhibiting mosquitoes from blood feeding and also killing mosquitoes [...] Resistance) and 2) Holed Net project. The ABCDR project aimed at understanding of bednet durability in malaria endemic countries and factors affecting bednet durability with the main focus of using that information
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Tropical parasitic diseases such as malaria, human African trypanosomiasis, Chagas disease, mycetoma, and leishmaniasis affect more than a billion people worldwide and have devastating consequences. There
Bayesian spatial models applied to malaria epidemiology (Publications)
scaling-up. Contemporary information on malaria prevalence for this work was provided mostly by Malaria Indicator Surveys (MIS) and Demographic Health Surveys (DHS) with malaria modules. MIS are nationally rep [...] impressive increases in international funding for malaria prevention, control, and elimination, which have led to tremendous expansion in implementing national malaria control programs (NMCPs). Common interventions [...] (MDG) 6 aims to halve malaria incidence by 2015 as compared to...
Predicting the impact of outdoor vector control interventions on malaria transmission intensity from semi-field studies (Publications)
important step in the development of novel vector control interventions against outdoor transmission of malaria since they provide good estimates of personal protection. However, it is often infeasible to determine [...] of semi-field data suggest that transfluthrin-treated eave ribbons are a promising tool against malaria transmission by An. arabiensis in the peridomestic area, since they provide both personal and community
A comparative evaluation of mobile medical APPS (MMAS) for reading and interpreting malaria rapid diagnostic tests (Publications)
Health Organization recommends confirmatory diagnosis by microscopy or malaria rapid diagnostic test (RDT) in patients with suspected malaria. In recent years, mobile medical applications (MMAs), which can interpret [...] falciparum blood samples at five dilutions ranging from 20 to 1000 parasites (p)/microlitre (microl) and malaria negative blood samples. The RDTs were performed in a controlled, laboratory setting by a trained [...] interpreting the Pf test line of RDTs at parasite densities...
Management of severe malaria cases learnings and challenges from the field (Publications)
A presentation on the management of severe malaria cases learnings and challenges from the field by Manuel Hetzel of the CARAMAL project.
Evaluating putative repellent 'push' and attractive 'pull' components for manipulating the odour orientation of host-seeking malaria vectors in the... (Publications)
BACKGROUND: Novel malaria vector control approaches aim to combine tools for maximum protection. This study aimed to evaluate novel and re-evaluate existing putative repellent 'push' and attractive 'pull' [...] 'pull' components for manipulating the odour orientation of malaria vectors in the peri-domestic space. METHODS: Anopheles arabiensis outdoor human landing catches and trap comparisons were implemented in [...] components led to a better understanding of their ability to affect...
