Christian Lengeler: Malaria breitet sich wieder aus [Radio Broadcast] (Publications)
Das Ziel der Weltgesundheitsorganisation: Malaria bis 2050 auszurotten. Noch immer sterben rund eine halbe Million Menschen jährlich an Malaria, die Zahl der Toten sinkt seit einigen Jahren nicht mehr
Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea (Publications)
BACKGROUND: Malaria transmission is currently resurging in Papua New Guinea (PNG). In addition to intervention coverage, social and cultural factors influence changes in epidemiology of malaria in PNG. This [...] in relation to current malaria control efforts. METHODS: A mixed-method design was used in 2 sites in PNG. In-depth interviews, focus group discussions, cross-sectional malaria indicator survey, and population [...] d in adult men. CONCLUSIONS: Our findings highlight the potential of...
Real-time dispersal of malaria vectors in rural Africa monitored with lidar (Publications)
observation of mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static [...] this study demonstrate how lidar-based monitoring could dramatically improve our understanding of malaria vector ecology and control options.
Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and... (Publications)
offers a tool for further studies on epigenetic regulation and life cycle decision in malaria parasites.IMPORTANCE Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate [...] The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes [...] domain and CSD of HP1 are functionally conserved between P....
Fine-scale distribution of malaria mosquitoes biting or resting outside human dwellings in three low-altitude Tanzanian villages (Publications)
investigated the distribution of malaria mosquitoes biting or resting outside dwellings in three low-altitude villages in south-eastern Tanzania. The likelihood of malaria infections outdoors was also assessed [...] proportion of non-human blood-meals and absence of malaria-infected mosquitoes after 12 months of nightly trapping suggests very low-levels of outdoor malaria transmission in these villages. [...] BACKGROUND: While malaria transmission in Africa still happens primarily inside houses,...
Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes (Publications)
and Anopheles species. We examined whether PPF added to larval habitats of pyrethroid-resistant malaria vectors can modulate levels of resistance among emergent adult mosquitoes. METHODOLOGY: Third-instar
Priority setting in HIV, tuberculosis, and malaria - new cost-effectiveness results from WHO-CHOICE (Publications)
cost-effectiveness of the selected interventions. Impact modelling was performed using the OpenMalaria platform for malaria and using the Goals and TIME (TB Impact Model and Estimates) models in Spectrum for HIV [...] interventions for HIV, TB and malaria were cost-effective, with cost-effectiveness ratios less than I$ 100/HLY saved for virtually all interventions included. HIV, TB and malaria prevention and treatment [...] the 21st century (2000-2010) with respect to allocative efficiency in...
Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite... (Publications)
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycl
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies (Publications)
Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)—variant surface antigens that are expressed on infected erythrocytes1—bind to the inhibitory receptor LAIR1, and in
Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
protection in African volunteers undergoing whole P. falciparum sporozoites-based malaria vaccination and controlled human malaria infections (CHMI). METHODS: HPgV-1 prevalence was quantified by RT-qPCR in plasma [...] levels among different populations pose a serious challenge to the development of an effective malaria vaccine. Co-infections are among many factors associated with immune dysfunction and sub-optimal
