Mass drug administration for malaria elimination: do we understand the settings well enough? (Publications)
tool for interrupting malaria transmission, but evidence from low endemicity settings is scarce. A trial in Zanzibar found that two rounds of MDA made no significant impact on malaria incidence, and many
Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
role of health service delivery to the malaria decline in Uganda We developed a methodology to quantify health facility readiness and assessed its role on severe malaria outcomes among lower-level facilities [...] facilities (HCIIIs and HCIIs) in the country. Malaria data was extracted from the Health Management Information System (HMIS). General service and malaria-specific readiness indicators were obtained from the [...] factorial axes. Geostatistical models assessed the effect of facility...
Mosquito repellents for malaria prevention (Review) (Publications)
BACKGROUND: Malaria is an important cause of illness and death across endemic regions. Considerable success against malaria has been achieved within the past decade mainly through long-lasting insecti [...] alone. It is unclear if topical repellents can prevent clinical malaria (RR 0.65, 95% CI 0.4 to 1.07, very low certainty evidence) or malaria infection (RR 0.84, 95% CI 0.64 to 1.12, low-certainty evidence) [...] repellentsTwo cluster-randomized RCTs investigated mosquito coils for malaria...
Antagonistic effects of <em>Plasmodium</em>-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire (Publications)
INTRODUCTION: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter t
Measuring and characterizing night time human behaviour as it relates to residual malaria transmission in sub-Saharan Africa: a review of the... (Publications)
broad categories: when and where people are exposed to malaria vectors and what people are doing at night that may increase their contact with malaria vectors. Among studies that quantified human-vector [...] BACKGROUND: Malaria cases and deaths decreased dramatically in recent years, largely due to effective vector control interventions. Persistence of transmission after good coverage has been achieved with [...] , namely insecticide-treated nets or indoor residual spraying, poses a...
Performance of antigen concentration thresholds for attributing fever to malaria among outpatients in Angola (Publications)
The density of malaria parasites is a key determinant in whether or not an infected individual develops fever. While the pyrogenic threshold for malaria parasite density has been well-studied, there is [...] latent-class modeling to attribute malaria etiology to the fevers and to estimate the sensitivity and specificity of different antigen thresholds for detecting malaria fevers. Amongst patients positive [...] febrile HRP2+ patients compared to afebrile HRP2+ patients. When considering HRP2...
Rapid multiplex gene expression assays for monitoring metabolic resistance in the major malaria vector <em>Anopheles gambiae</em> (Publications)
BACKGROUND: Metabolic resistance of the major malaria vector Anopheles gambiae (s.l.) to insecticides is operationally significant, particularly in combination with target site resistance. However, detection
Early antischistosomal leads identified from<em> in vitro</em> and<em> in vivo</em> screening of the Medicines for Malaria Venture pathogen box (Publications)
Facing an almost dry drug development pipeline, screening the Pathogen Box from the Medicines for Malaria Venture (MMV), provides a unique opportunity to possibly expand the pool of potent molecules against