Field evaluation of a volatile pyrethroid spatial repellent and etofenprox treated clothing for outdoor protection against forest malaria vectors in... (Publications)
Cambodia's goal to eliminate malaria by 2025 is challenged by persistent transmission in forest and forest fringe areas, where people are exposed to Anopheles mosquito bites during the day and night. Volatile [...] the potential to reduce outdoor and daytime Anopheles biting, offering valuable contributions to malaria elimination efforts in Cambodia and the Greater Mekong Subregion, contingent upon achieving effective
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of [...] Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing. SW584 had a low propensity to generate resistance (minimum inoculum for resistance
Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region [...] of quintuple-mutant parasites and the clinical consequences. METHODS: We used an individual-based malaria transmission model with explicit parasite dynamics and drug pharmacological models to identify and [...] deployment strategies. We estimated the impact of this spread on SMC effectiveness...
Travel to malaria-endemic areas: using digital geo-location to assess potential exposure risks and health behaviours (Publications)
and Tanzania, each presenting varying malaria risks. The extent to which travellers enter high-risk malaria-endemic areas in destinations with heterogeneous malaria risk remains unclear. We used geo-location [...] heterogeneous malaria risk (Brazil, India, Peru, Thailand), and (ii) compare mosquito bite prevention behaviours between these destinations and Tanzania, considered entirely high-risk for malaria. METHODS: [...] health and geo-location data were collected using a smartphone...
The effects of climatic and non-climatic factors on malaria mortality at different spatial scales in western Kenya, 2008-2019 (Publications)
relatively small size of the HDSS, there was spatial variation in malaria mortality that peaked every May-June. The rapid decline in malaria mortality was associated with bed nets, and finer spatial scale [...] BACKGROUND: Malaria mortality is influenced by several factors including climatic and environmental factors, interventions, socioeconomic status (SES) and access to health systems. Here, we investigated [...] ed the joint effects of climatic and non-climatic factors on under-five malaria...
Evaluation of malaria rapid diagnostic test performance and <em>pfhrp2</em> deletion in Tanzania school surveys, 2017 (Publications)
As part of malaria nationwide monitoring and evaluation initiatives, there is an increasing trend of incorporating malaria rapid diagnostic tests (mRDTs) in surveys conducted within primary schools to [...] to detect malaria parasites. However, mRDTs based on the detection of histidine-rich protein 2 (HRP2) are known to yield false-positive results due to persistent antigenemia, and false-negative results may
Design and selection of drug properties to increase the public health impact of next-generation seasonal malaria chemoprevention: a modelling study (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) is recommended for disease control in settings with moderate to high Plasmodium falciparum transmission and currently depends on the administration of [...] threaten the effectiveness of SMC. Guidance is needed to de-risk the development of drug compounds for malaria prevention. We aimed to provide guidance for the early prioritisation of new and alternative SMC [...] their target product profiles. METHODS: In this modelling study, we combined...
Correction: Testing and treatment for malaria elimination: a systematic review (Publications)
Correction: Malaria Journal (2023) 22:254 https://doi.org/10.1186/s12936-023-04670-8