Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
reaction (PCR) analyses. Data on confirmed malaria infections from health facilities in intervention and hotspot control areas were monitored as proxy for malaria transmission. RESULTS: Approximately 64% [...] carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT [...] BACKGROUND: Seasonal increases in malaria continue in hotspots in...
Acquisition of antibodies against <em>Plasmodium falciparum</em> merozoites and malaria immunity in young children: influence of age, force of... (Publications)
levels were not associated with protection from malaria; in contrast, they were typically associated with an increased risk of malaria. Adjustment for malaria exposure, using a novel molecular measure of [...] subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children aged 1-4yrs in a malaria endemic region of Papua New Guinea. IgG, IgG1 and IgG3 responses generally increased [...] required for protection from malaria. Our results suggest that in...
Relationship between humoral response to <em>Plasmodium falciparum</em> merozoite surface antigen-2 and malaria morbidity in a highly endemic area of... (Publications)
of MSA-2 are associated with fewer fever episodes and less anemia, both known to be indicators of malaria morbidity.
Humoral and cell-mediated immunity to the <em>Plasmodium falciparum</em> ring-infected erythrocyte surface antigen in an adult population exposed to... (Publications)
in Papua New Guinea highly endemic for malaria. Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte [...] to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast,
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
were the occurrence of malaria over 12 months after dose 3 in each age category. In this final analysis, we present data for the efficacy of the booster on the occurrence of malaria. Vaccine efficacy (VE) [...] (VE) against clinical malaria was analysed by negative binomial regression and against severe malaria by relative risk reduction. This trial is registered with ClinicalTrials.gov, number NCT00866619. FINDINGS: [...] children who experienced at least one episode of severe malaria in the...
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating [...] combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of [...] dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical...