Relationship between humoral response to <em>Plasmodium falciparum</em> merozoite surface antigen-2 and malaria morbidity in a highly endemic area of... (Publications)
of MSA-2 are associated with fewer fever episodes and less anemia, both known to be indicators of malaria morbidity.
Humoral and cell-mediated immunity to the <em>Plasmodium falciparum</em> ring-infected erythrocyte surface antigen in an adult population exposed to... (Publications)
in Papua New Guinea highly endemic for malaria. Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte [...] to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast,
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
were the occurrence of malaria over 12 months after dose 3 in each age category. In this final analysis, we present data for the efficacy of the booster on the occurrence of malaria. Vaccine efficacy (VE) [...] (VE) against clinical malaria was analysed by negative binomial regression and against severe malaria by relative risk reduction. This trial is registered with ClinicalTrials.gov, number NCT00866619. FINDINGS: [...] children who experienced at least one episode of severe malaria in the...
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating [...] combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of [...] dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical...
The use of untreated bednets and malaria infection, morbidity and immunity (Publications)
bednets. Thus, untreated bednets do not reduce malaria transmission sufficiently to decrease morbidity. They might paradoxically increase the risk of clinical malaria by lowering the development of humoral immunity
Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania (Publications)
Histidine-rich protein II (HRP2)-based malaria rapid diagnostic tests (RDTs) have shown high sensitivity and specificity for detecting Plasmodium falciparum malaria in a variety of study settings. However [...] their use in field settings. We evaluated sensitivity and specificity of RDTs during routine use for malaria case management in peripheral health facilities. From December 2007 to October 2008, HRP2-based ParaHIT-f [...] thick blood smear. Job aids, Integrated Management of Childhood...
