Knowledge of antimalarials and health seeking behaviour of households in case of suspected malaria in Democratic Republic of the Congo (Publications)
of the Congo (DRC) is heavily affected by malaria despite availability of effective treatments. Ignorance and unrecommended behaviour toward a suspected malaria case in households may contribute to this [...] urban Health Centres in each of the 11 previous provinces of DRC, all households with a case of malaria in the 15 days prior to the survey were selected. The patient or caregiver (responder) were interviewed [...] predictors of knowledge of recommended antimalarials and adequate behaviour...
Safety, immunogenicity and efficacy of PfSPZ vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase... (Publications)
infection in malaria-naive adults. Preclinical studies show that T cell-mediated immunity is required for protection and is readily induced in humans after vaccination. However, previous malaria exposure can [...] and vaccine efficacy (VE) in adults. We hypothesized that infants with less previous exposure to malaria would have improved immunity and protection. We conducted a multi-arm, randomized, double-blind, [...] tolerability, immunogenicity and efficacy of the PfSPZ Vaccine in infants in a...
Transfluthrin eave-positioned targeted insecticide (EPTI) reduces human landing rate (HLR) of pyrethroid resistant and susceptible malaria vectors in... (Publications)
of transfluthrin eave-positioned targeted insecticide (EPTI) depends on the resistance status of malaria vectors. METHODS: Ribbons treated with 5.25 g transfluthrin or untreated controls were used around
Evaluation of different deployment strategies for larviciding to control malaria: a simulation study (Publications)
METHODS: A malaria transmission model, OpenMalaria, was used to simulate varying larviciding strategies and their impact on host-seeking mosquito densities, entomological inoculation rate (EIR) and malaria prevalence [...] BACKGROUND: Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary [...] g were simulated for three transmission intensities and four...
Incidence of <em>Plasmodium falciparum</em> malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea (Publications)
were 58 malaria infection episodes observed during the follow up period, including 47 first and 11 repeat infections. The incidence of malaria was 0.25 [95% CI (0.19, 0.32)] and of first malaria was 0.23 [...] study area, gender, malaria positivity at screening, and household socioeconomic status independently predicted the observed incidence of malaria. CONCLUSION: Despite intensive malaria control efforts on [...] BACKGROUND: Extensive malaria control measures have been implemented on Bioko...
Analysis of contamination in cluster randomized trials of malaria interventions (Publications)
BACKGROUND: In cluster randomized trials (CRTs) of interventions against malaria, mosquito movement between households ultimately leads to contamination between intervention and control arms, unless they [...] which contamination measurably biases the estimate of effectiveness. A sigmoid function is fitted to malaria prevalence or incidence data as a function of the distance of households to the intervention boundary
Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea (Publications)
Malaria risk is highly heterogeneous. Understanding village and household-level spatial heterogeneity of malaria risk can support a transition to spatially targeted interventions for malaria elimination [...] spatial heterogeneity of malaria risk and investigate the contribution of individual, household and environmental-level risk factors. Following a period of declining malaria prevalence, the prevalence [...] useful indicators of transmission hotspots and inform the development of tailored...
Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials? (Publications)
used to distinguish genotyping 'noise' from real low density signals, the local epidemiology of malaria transmission, and the potential impact of genetic signals from gametocytes. Results. AmpSeq greatly
