Increased use of malaria rapid diagnostic tests improves targeting of anti-malarial treatment in rural Tanzania: implications for nationwide rollout... (Publications)
Health Organization recommends parasitological confirmation of all malaria cases. Tanzania is implementing a phased rollout of malaria rapid diagnostic tests (RDTs) for routine use in all levels of care [...] confirmation of malaria diagnosis. This study was carried out to evaluated artemisinin combination therapy (ACT) prescribing patterns in febrile patients with and without uncomplicated malaria in one pre-RDT [...] and low malaria transmission seasons in 2010 in both areas. Clinical...
The use of insecticide-treated nets for reducing malaria morbidity among children aged 6-59 months, in an area of high malaria transmission in central... (Publications)
tool for controlling malaria. Much attention has been devoted to determine both the effect of LLINs on the reduction of Plasmodium infection rate and clinically-confirmed malaria cases in sub-Saharan Africa [...] of clinically-confirmed malaria cases, in five villages in the district of Toumodi, central Cote d'Ivoire. METHODS: From April 2007 to November 2008, a community-based malaria control programme was implemented [...] overall clinical malaria rates dropped over the entire 18-month project...
Cost-effectiveness of iron supplementation and malaria chemoprophylaxis in the prevention of anaemia and malaria among Tanzanian infants (Publications)
year (DALY) for malaria chemoprophylaxis with Deltaprim (a combination of 3.125 mg pyrimethamine and 25 mg dapsone) + iron, Deltaprim alone, or iron supplementation alone. For malaria prevention, Deltaprim [...] were less costly than the current malaria and anaemia control strategies that rely on clinical case management. This economic analysis supports the inclusion of both malaria chemoprophylaxis and iron supp [...] Prerequisites for effective interventions against severe anaemia and malaria...
Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate [...] clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network [...] network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second [...] methods commonly used in malaria epidemiology and population genetics....
Comprehensive sterilization of malaria vectors using pyriproxyfen: a step closer to malaria elimination (Publications)
One of the main challenges to malaria elimination is the resilience of vectors, such as Anopheles arabiensis, that evade lethal exposure to insecticidal control measures or express resistance to their
Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using cryopreserved [...] sporozoites provide a unique opportunity to study differences in acquisition or re-call of anti-malaria immune responses in individuals from different transmission settings and genetic backgrounds. In [...] In this study, we compared anti-parasite humoral and cellular immune...
Relationship between child survival and malaria transmission: an analysis of the malaria transmission intensity and mortality burden across Africa... (Publications)
relationship between malaria mortality and levels of transmission is unclear. Due to methodological limitations, earlier efforts to assess the linkage have lead to inconclusive results. The malaria transmission [...] assessing the malaria transmission-mortality relation involves more than the knowledge on the performance of interventions and control measures. This relation depends on the levels of malaria endemicity and [...] age and insecticide-treated nets (ITNs), were fitted to assess the...