Identification of new human malaria parasite <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase inhibitors by pharmacophore and... (Publications)
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on exclusively for survival, has emerg
Comparative performance of three experimental hut designs for measuring malaria vector responses to insecticides in Tanzania (Publications)
BACKGROUND: Experimental huts are simplified, standardized representations of human habitations that provide model systems to evaluate insecticides used in indoor residual spray (IRS) and long-lasting
Critical evaluation of molecular monitoring in malaria drug efficacy trials and pitfalls of length-polymorphic markers (Publications)
therefore calls for necessary amendments to the current WHO recommendations for PCR correction of malaria drug trial endpoints. Accuracy of genotyping outcomes could be improved by separate amplification
Estimating malaria transmission intensity from <em>Plasmodium falciparum</em> serological data using antibody density models (Publications)
BACKGROUND: Serological data are increasingly being used to monitor malaria transmission intensity and have been demonstrated to be particularly useful in areas of low transmission where traditional measures
The effects of an oil and wheat flour fortification program on pre-school children and women of reproductive age living in Côte d'Ivoire, a... (Publications)
Anemia and micronutrient deficiencies are widespread in sub-Saharan Africa, but the impact of food fortification is still debated. The objective of this study was to estimate the iron and vitamin A st
Malaria elimination: moving forward with spatial decision support systems (Publications)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response in [...] mapping and geographical reconnaissance (GR) has traditionally played an important role in supporting malaria control and eradication, its full potential as an applied health systems tool has not yet been fully [...] spatial decision support system (SDSS) framework for supporting the...
Safety, tolerability and immunogenicity of new formulations of the <em>Plasmodium falciparum </em>malaria peptide SPf66 combined with the... (Publications)
SPf66 is a synthetic malaria peptide vaccine, which has been widely tested in combination with aluminium hydroxide (alum) as the adjuvant. Since this formulation is weakly immunogenic, we sought to improve
Exploring the contributions of bed nets, cattle, insecticides and excitorepellency to malaria control: a deterministic model of mosquito host-seeking... (Publications)
Domestic and personal protection measures against malaria exposure either divert host-seeking vectors to other hosts or kill those attempting to feed. Here, we explicitly model mosquito host-seeking processes [...] technology and distribution systems for insecticide-treated nets improve, massive reductions in malaria transmission could be realised