Recherche de Malaria.

1. Microsatellite DNA polymorphism and heterozygosity in the malaria vector mosquito <em>Anopheles funestus</em> (Diptera: Culicidae) in east and... (Publications)

   Microsatellite DNA polymorphism and heterozygosity in the malaria vector mosquito <em>Anopheles funestus</em> (Diptera: Culicidae) in east and southern Africa

   Pertinence:

   There has been an increase in malaria cases in southern African countries in recent years due to the presence of populations of Anopheles funestus that are resistant to the pyrethroid class of insecticides [...] insecticides. Since A. funestus is one of the major African malaria vectors, knowledge of its genetic structure will benefit control strategies, such as the management of insecticide resistance, by allowing

2. Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria (Publications)

   Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria

   Pertinence:

   pharmacokinetic profile of the series translated to exceptional oral efficacy in the P. berghei infected malaria mouse model where full cure was achieved in four of five mice with three daily doses of 30 mg/kg

3. Molecular epidemiology of <em>Plasmodium falciparum</em> in areas of different malaria endemicity-Tanzania (Publications)

   Molecular epidemiology of <em>Plasmodium falciparum</em> in areas of different malaria endemicity-Tanzania

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4. Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital (Publications)

   Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital

   Pertinence:

   severe malaria. RESULTS: Seven thousand and forty-three children were admitted with a diagnosis of malaria. 25.2% fulfilled the criteria for severe malaria. 5.4% of the children with severe malaria and valid [...] rates of severe malaria cases rose steeply when bacteraemia was also present (from 4.0% to 22.0%, P < 0.0001), and bacteraemia was an independent risk factor for death among severe malaria patients (adjusted [...] associated with severe malaria syndromes, or anaemia severity groups. No...

5. The public health impact and cost-effectiveness malaria vaccine RTS,S/AS01 prior to a WHO policy recommendation : a systematic comparison of... (Publications)

   The public health impact and cost-effectiveness malaria vaccine RTS,S/AS01 prior to a WHO policy recommendation : a systematic comparison of predictions and mathematical models

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6. Bayesian modelling of geostatistical malaria risk data (Publications)

   Bayesian modelling of geostatistical malaria risk data

   Pertinence:

7. The reltive improtance of malaria vaccine properties (Publications)

   The reltive improtance of malaria vaccine properties

   Pertinence:

8. A cross-over study to evaluate the diversion of malaria vectors in a community with incomplete coverage of spatial repellents in the Kilombero Valley,... (Publications)

   A cross-over study to evaluate the diversion of malaria vectors in a community with incomplete coverage of spatial repellents in the Kilombero Valley, Tanzania

   Pertinence:

9. Novel inhibitors of <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase exhibit anti-malaria activity in murine models (Publications)

   Novel inhibitors of <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase exhibit anti-malaria activity in murine models

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10. Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study (Publications)

    Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study

    Pertinence:

    OBJECTIVE: To compare the tolerability of malaria chemoprophylaxis regimens in non-immune travellers. DESIGN: Randomised, double blind, study with placebo run-in phase. SETTING: Travel clinics in Switzerland