Acquisition of antibodies against <em>Plasmodium falciparum</em> merozoites and malaria immunity in young children: influence of age, force of... (Publications)
levels were not associated with protection from malaria; in contrast, they were typically associated with an increased risk of malaria. Adjustment for malaria exposure, using a novel molecular measure of [...] subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children aged 1-4yrs in a malaria endemic region of Papua New Guinea. IgG, IgG1 and IgG3 responses generally increased [...] required for protection from malaria. Our results suggest that in...
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
reaction (PCR) analyses. Data on confirmed malaria infections from health facilities in intervention and hotspot control areas were monitored as proxy for malaria transmission. RESULTS: Approximately 64% [...] carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT [...] BACKGROUND: Seasonal increases in malaria continue in hotspots in...
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the [...] vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose [...] against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the...
A low-cost mesocosm for the study of behaviour and reproductive potential in Afrotropical mosquito (Diptera: Culicidae) vectors of malaria (Publications)
ss for use in experiments on behaviour, reproduction and adult survivorship in the Afrotropical malaria vector Anopheles gambiae s.s. Giles (Diptera: Culicidae) in temperate climates. The large space (82
Pharmacokinetics-pharmacodynamics analysis of spiroindolone analogs and KAE609 in a murine malaria model (Publications)
selected class representative. Dose-response efficacy studies were conducted in the P. berghei murine malaria model and the relationship between dose and efficacy (i.e. reduction in parasitemia) was examined [...] of 30 are likely to result in maximum reduction in parasitemia in the P. berghei mouse model of malaria. This information could be used to prioritize analogs within the same class of compounds and contribute
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries (Publications)
sector is an important source of treatment for malaria. However, private patients face high prices for the recommended treatment for uncomplicated malaria, artemisinin combination therapies (ACTs), which
Defining the relationship between infection prevalence and clinical incidence of<em> Plasmodium falciparum</em> malaria (Publications)
falciparum malaria cases. In response, cartographic approaches have been developed that link maps of infection prevalence with mathematical relationships to predict the incidence rate of clinical malaria. Mi
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
clinical malaria in which parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as compared with 33.4% (95% CI, 29.3 to 37.2) against mismatched malaria (1951 [...] age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category [...] protein of Plasmodium falciparum and has partial protective efficacy against...
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with