Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
clinical malaria in which parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as compared with 33.4% (95% CI, 29.3 to 37.2) against mismatched malaria (1951 [...] age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category [...] protein of Plasmodium falciparum and has partial protective efficacy against...
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with
The elderly, the young and the pregnant traveler - a retrospective data analysis from a large Swiss Travel Center with a special focus on malaria... (Publications)
in Switzerland especially focusing on travel to yellow fever and malaria-endemic countries, and yellow fever vaccination (YFV) and malaria medications. METHOD: An analysis of pre-travel visits between 2010 [...] months was vaccinated. 80% of young travelers and a similar percentage of pregnant women went to malaria-endemic regions. Twenty-five pregnant/breastfeeding women traveled to YF endemic areas. CONCLUSIONS: [...] vulnerable travelers are comparable to those of other travelers. In view of...
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen [...] enzymesubstrate complex. These results validate PfAp3Aase as a new drug target for the treatment of malaria. We have previously elucidated the structurally unrelated regulatory subunit ClpC1 of the ClpP protease
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
injectable PfSPZ-based vaccine that provides high grade, durable protection against infection with Pf malaria. Several candidate vaccines are being developed and tested, including PfSPZ Vaccine, in which the [...] and long-term objectives for a final product suitable for mass administration to achieve regional malaria elimination and eventual global eradication
The architecture and effect of participation: a systematic review of community participation for communicable disease control and elimination.... (Publications)
successful disease control and elimination campaigns in many countries. Despite this, its benefits for malaria control and elimination are yet to be fully realized. This may be due to a limited understanding [...] participation for communicable disease control and elimination and provide guidance for the current malaria elimination campaign. METHODS: Evidence derived from quantitative research was considered both i [...] communicable disease control and elimination which is presented herein....
The synthetic<em> Plasmodium falciparum</em> circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial (Publications)
Plasmodium falciparum circumsporozoite protein (PfCS102) in malaria naive adults. METHODOLOGY AND PRINCIPAL FINDINGS: Thirty-six healthy malaria-naive adults were randomly distributed into three dose blocks [...] BACKGROUND: Fully efficient vaccines against malaria pre-erythrocytic stage are still lacking. The objective of this dose/adjuvant-finding study was to evaluate the safety, reactogenicity and immunogenicity
Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control (Publications)
awaiting for the arrival of an effective and affordable malaria vaccine, there is a need to make use of the available control tools to reduce malaria risk, especially in children under five years and pregnant [...] important component of the malaria control strategy. This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness [...] of febrile malaria illness, impacts significantly on the parasite...
Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions - a user perspective (Publications)
Treatment-seeking and awareness of malaria was already high at baseline, but various improvements were seen between 2004 and 2008, namely: better understanding causes of malaria (from 62% to 84%); an increase [...] approach aimed at improving understanding and treatment of malaria has led to tangible improvements in terms of people's actions for the treatment of malaria. However, progress was hindered by the low availability [...] BACKGROUND: The ACCESS programme aims at understanding and...
Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug... (Publications)
Dispensing Outlets (ADDO) was created in Tanzania. Tanzania changed its first-line treatment for malaria from sulphadoxine-pyrimethamine (SP) to artemether-lumefantrine (ALu) in 2007. Subsidized ALu was [...] made available in both health facilities and ADDOs. The effect of these interventions on access to malaria treatment was studied in rural Tanzania. METHODS: The study was carried out in the villages of Kilombero [...] outlets. The data were complemented with DSS population data. RESULTS:...
