The acceptability of intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in... (Publications)
BACKGROUND: Intermittent preventive treatment of malaria in infants (IPTi) reduces the incidence of clinical malaria. However, before making decisions about implementation, it is essential to ensure that [...] attitudes or adherence to the expanded programme on immunisation (EPI) or treatment seeking or existing malaria prevention. CONCLUSION: In order to improve adherence to both EPI and IPTi local priorities should
Allomonal effect of breath contributes to differential attractiveness of humans to the African malaria vector Anopheles gambiae (Publications)
contributes to between-person differences in relative attractiveness to the highly anthropophilic malaria vector Anopheles gambiae sensu stricto remains unknown and was the focus of the present study. METHODS: [...] contributor to between-person differences in the relative attractiveness of humans to this important malaria vector
Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity (Publications)
Individuals in a malaria endemic community differ from one another. Many of these differences, such as heterogeneities in transmission or treatment-seeking behaviour, affect malaria epidemiology. The [...] heterogeneity were incorporated into a comprehensive individual-based model of Plasmodium falciparum malaria epidemiology. The different types of heterogeneity were systematically simulated individually, and
Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
seasonality, proportions of malaria fevers treated and drug characteristics. METHODS: We use a dynamic, individual-based simulation model of Plasmodium falciparum malaria epidemiology, antimalarial drug [...] preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness. The effects of different intervention [...] g and more expensive drugs, high frequencies of drug resistance and high levels...
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
developed severe malaria while 6/137 of both RDT and BS positive did so. The use of RDT allowed a reduction of a median of 2.1 hours to get a first malaria test result.CONCLUSIONS: A malaria diagnostic strategy [...] tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diagnose falciparum malaria based on [...] those, 2/2028 (0.1%) developed uncomplicated malaria with both RDT and BS...
Experience and challenges from clinical trials with malaria vaccines in Africa (Publications)
clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, [...] Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort [...] Despite this, there is currently no licensed malaria vaccine. Researchers,...
Reduced risk of <em>Plasmodium vivax</em> malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control... (Publications)
protection against P. vivax malaria by a mechanism that is independent of the Duffy antigen. P. vivax malaria may have contributed to shaping the unique host genetic adaptations to malaria in Asian and Oceanic [...] a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Delta27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against
Malaria knowledge and long-lasting insecticidal net use in rural communities of central Côte d'Ivoire (Publications)
BACKGROUND: To improve effectiveness of malaria control interventions, it is essential to deepen the knowledge of contextual factors that govern people's practice for preventive and curative measures. [...] N'Dakonankro and Yoho) located in central Cote d'Ivoire. Indicators of socioeconomic position (SEP), malaria knowledge and practice, placing special emphasis on LLINs, were investigated during a cross-sectional [...] were used, as appropriate. RESULTS: Significant differences were found...
Ensemble modeling of the likely public health impact of a pre-erythrocytic malaria vaccine (Publications)
BACKGROUND: The RTS,S malaria vaccine may soon be licensed. Models of impact of such vaccines have mainly considered deployment via the World Health Organization's Expanded Programme on Immunization (EPI)
<em>Anopheles plumbeus</em> (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? (Publications)
of humans between Europe and malaria endemic countries and changes in environment and climate, these data strongly suggest that An. plumbeus could act as a vector for malaria and thus significantly contribute [...] to increasing the malaria transmission risk in Central-Western Europe. In locations showing high vulnerability to the presence of gametocyte carriers, the risk of transmission of malaria by An. plumbeus [...] ABSTRACT: BACKGROUND: Anopheles plumbeus has been recognized as a minor...