Effect of the malaria vaccine combination B on merozoite surface antigen 2 diversity (Publications)
Plasmodium falciparum surface antigens. This poses a considerable obstacle to the development of a malaria vaccine. In order to assess possible effects of a polymorphic vaccine, we have analyzed the genetic
Asexual blood-stage malaria vaccine development: facing the challenges (Publications)
reduce morbidity. RECENT FINDINGS: There is good rationale to support the development of blood-stage malaria vaccines, the most promising being the demonstration that nonimmune volunteers repeatedly challenged [...] as well as the demonstration of the efficacy of the first asexual blood-stage vaccine tested in a malaria endemic area (combination B) to reduce parasite density in children. The selective pressure induced
Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates (Publications)
peptide-specific antibodies in human immune sera were associated with protection from clinical malaria. The synthetic fragments share major antigenic properties with native MSP2. Immunization of mice