The economic payoffs of integrated malaria control in the Zambian copperbelt between 1930 and 1950 (Publications)
suggested that malaria is delaying the economic development of countries that are most severely affected by the disease. Several studies have documented the economic consequences of malaria at the household [...] economic impact of malaria on the industrial and service sectors that will probably become the backbone of many developing economies. We estimate the economic effects of integrated malaria control implemented [...] 284 malaria attacks and 942,347 work shift losses were averted. Overall,...
A <em>var</em> gene promoter controls allelic exclusion of virulence genes in <em>Plasmodium falciparum</em> malaria (Publications)
proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte
Cost savings with rapid diagnostic tests for malaria in low-transmission areas: evidence from Dar es Salaam, Tanzania (Publications)
Rapid diagnostic tests (RDTs) for malaria may help rationalize antimalarial drug use. However, the economic effects of these tests may vary. Data on costs were collected from 259 patients in 6 health
Optimized Malaria-antigens delivered by immunostimulating reconstituted influenza virosomes (Publications)
Malaria remains a serious cause of morbidity and mortality in millions of individuals each year. The development of widespread resistance of the parasite to drugs as well as resistance of the transmitting [...] transmitting mosquito-vector to insecticides in combination with the poor economic situation of many malaria-endemic countries make the development of an effective and inexpensive treatment and prevention a main [...] appropriate conformation. Here, we review the development of a new...
Vaccines against malaria: perspectives from Papua New Guinea (Publications)
perspectives on malaria vaccines. Building on a long history of malaria research, in this article we review past achievements, highlight current research and outline future directions in malaria vaccine research [...] transmission of all four species of human malaria, a full range of malaria endemicities, well described epidemiology and a demonstrated capacity to evaluate a malaria vaccine, PNG currently has the only field [...] Despite its small population and isolated location Papua New Guinea...
<em>In vitro</em> screening of traditional South African malaria remedies against <em>Trypanosoma brucei rhodesiense</em>, <em>Trypanosoma cruzi,... (Publications)
Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened IN VITRO for activity against TRYPANOSOMA BRUCEI RHODESIENSE, TRYPANOSOMA CRUZI, LEISHMANIA
Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya (Publications)
Background. Clear case definitions of malaria are an essential means of evaluating the effectiveness of present and proposed interventions in malaria. The clinical signs of malaria are nonspecific, and parasitemia [...] episode of clinical malaria in endemic areas. We defined and quantified cases of malaria in people of different age groups from 2 areas with different rates of transmission of malaria.Methods. A total of [...] of malaria.Results. Two case definitions of malaria were derived: 1...
The sensitivity of the OptiMAL rapid diagnostic test to the presence of <em>Plasmodium falciparum </em>gametocytes compromises its ability to monitor... (Publications)
Using in vivo samples from treatment failure malaria cases, we demonstrate the high sensitivity of the parasite lactase dehydrogenase (pLDH)-based OptiMAL rapid diagnostic test in the detection of P.