Managing the sick child in the era of declining malaria transmission: development of ALMANACH, an electronic algorithm for appropriate use of... (Publications)
based on a respiratory rate threshold of 50 assessed twice for febrile children 12-59 months; iv) malaria rapid diagnostic test performed for all febrile children. In the absence of identified source of
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient... (Publications)
d Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria. METHODS: Individual patient
Applications and limitations of Centers for Disease Control and Prevention miniature light traps for measuring biting densities of African malaria... (Publications)
BACKGROUND: Measurement of densities of host-seeking malaria vectors is important for estimating levels of disease transmission, for appropriately allocating interventions, and for quantifying their impact [...] methods for their consistency in sampling indoor-feeding mosquitoes belonging to the two major taxa of malaria vectors across Africa, the Anopheles gambiae sensu lato complex and the Anopheles funestus s.l. group [...] easy to deploy on a large scale. Spatial and temporal variation in...
Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study (Publications)
Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not [...] shifting of incidence induced by either pre-erythrocytic vaccination (PEV) programmes or seasonal malaria chemo-prevention (SMC), using an ensemble of individual-based stochastic simulation models of P. [...] life-cycle and on human demography. Effects of transmission intensity, and of...
Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment (Publications)
BACKGROUND: Malaria prevalence, clinical incidence, treatment, and transmission rates are dynamically interrelated. Prevalence is often considered a measure of malaria transmission, but treatment of clinical [...] clinical malaria reduces prevalence, and consequently also infectiousness to the mosquito vector and onward transmission. The impact of the frequency of treatment on prevalence in a population is generally [...] generally not considered. This can lead to potential underestimation of ma...
<em>Plasmodium falciparum</em> cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report... (Publications)
The case of a 56-year-old female tourist who survived cerebral Plasmodium falciparum malaria with disseminated intravascular coagulation and symmetrical peripheral gangrene, ultimately requiring amputation [...] gangrene has been described rarely in Asian, African, and American patients with Plasmodium falciparum malaria and disseminated intravascular coagulation, no such case has been reported in travelers returning
Factors influencing the pattern of imported malaria (Publications)
imported malaria in industrialized areas are known to be incomplete because of underreporting and lack of homogeneity. These facts and the complexity of factors influencing the transmission of malaria render [...] duration of stay on the latency of malaria attacks. African origin and repeated stays were confounders with regard to adherence to chemoprophylaxis. The local situation of malaria transmission and the development [...] to influence the evolution of malaria rates. These factors must be...
