Early whole blood transcriptional responses to radiation-attenuated <em>Plasmodium falciparum</em> sporozoite vaccination in malaria naive and malaria... (Publications)
radiation-attenuated P. falciparum sporozoites were analysed and compared across malaria-naive adult participants (IMRAS) and malaria-experienced adult participants (BSPZV1). Parasite dose and method of delivery [...] despite stark differences between the two studies, including route of vaccination and status of malaria exposure, responses were identified that were associated with protection after PfRAS vaccination
The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control... (Publications)
sufficient for malaria elimination. The effects of community-based house improvement (HI) and larval source management (LSM) as supplementary interventions to the Malawi National Malaria Control Programme [...] tion indicated a promising reduction in malaria transmission for the area, but also limited the usefulness of this outcome for measuring differences in malaria transmission among the trial arms. Trial [...] bed net use, neither community-based HI, LSM, nor HI + LSM contributed to further...
Closing the malaria prevention gap: measuring and characterizing human behavioral drivers of persistent malaria transmission in Sub-Saharan Africa (Publications)
two-thirds of the reduction in malaria burden over the past two decades. However, progress has begun to stall in recent years highlighting the importance of enhanced malaria prevention efforts. The aim of [...] Malaria kills a person nearly every minute, most often a child under the age of five. While endemic in many parts of the world, a disproportionate burden of cases and deaths are borne by people living [...] living in sub-Saharan Africa. Malaria is transmitted by the female Anopheles...
Constructing a malaria-related health service readiness index and assessing its association with child malaria mortality: an analysis of the Burkina... (Publications)
services. We constructed a readiness index related to malaria services and determined the association between health facility malaria readiness and malaria mortality in children under the age of 5 years in [...] l models with variable selection were fitted to malaria mortality data. The most important facility readiness indicators related to general and malaria-specific services were determined. Multiple corr [...] the low readiness group. Medical centres readiness was not related to malaria...
Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of... (Publications)
FGDs showed that participants had good knowledge about malaria symptoms, prevention tools, and effective treatment. Behaviour change regarding malaria treatment and free medication for children under five [...] CONCLUSIONS: The study showed appropriate knowledge about malaria and positive community care-seeking behaviour at health centres for fever/malaria episodes. This could potentially facilitate the implementation [...] BACKGROUND: Malaria case management relies on World Health Organization...
Reflections on the 2021 World Malaria Report and the future of malaria control (Publications)
The World Malaria Report, released in December 2021, reflects the unique challenges currently facing the global malaria community. The report showed the devastating toll of malaria, with an estimated 627 [...] the capacity of the continent to address the malaria challenge. African countries also face a convergence of biological threats that could redefine malaria control, notably widespread pyrethroid resistance [...] presents key insights from the 2021 World Malaria Report and reflections on...
Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: secondary analysis of a household-randomised,... (Publications)
s 0.13 (95% CI: 0.08, 0.20), P < 0.001 for malaria hospitalisations and deaths from malaria and 0.21 (95% CI 0.20, 0.23), P < 0.001 for uncomplicated malaria, indicating protective efficacy of 87.4% (95% [...] BACKGROUND: Seasonal malaria chemoprevention (SMC) is now widely deployed in the Sahel, including several countries that are major contributors to the global burden of malaria. Consequently, it is important [...] coverage and high adherence to SMC, the incidence of hospitalisations or...
Effectiveness of the innovative 1,7-malaria reactive community-based testing and response (1, 7-mRCTR) approach on malaria burden reduction in... (Publications)
n Tanzania to explore a new model for reducing malaria burden and possibly scaling-out the approach into other malaria-endemic countries. The 1,7-malaria Reactive Community-based Testing and Response (1 [...] activities implemented in the intervention arm included community testing and treatment of malaria infection. Malaria case-to-suspect ratios at health facilities (HF) were aggregated by villages, weekly to [...] wards to assess the change in malaria prevalence measured by the interaction...