Malaria-infected mice are cured by oral administration of new artemisinin derivatives (Publications)
a new series of 23 trioxane dimers has been prepared. Eleven of these new trioxane dimers cure malaria-infected mice via oral dosing at 3 x 30 mg/kg. The clinically used trioxane drug sodium artesunate [...] on day 6-7 postinfection. At only 3 x 10 mg/kg oral dosing, seven dimers prolong the lifetime of malaria-infected mice to days 14-17, more than double the chemotherapeutic effect of sodium artesunate. Ten
Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of <em>Plasmodium</em> (Publications)
that P. malariae infection protects against disease, but indicated greater protection against non-malaria than P. falciparum- associated fevers. Plasmodium vivax appeared to protect against P. falciparum [...] variables may account for many differences among reports of inter-species interactions in human malaria
Towards a comprehensive simulation model of malaria epidemiology and control (Publications)
SUMMARYPlanning of the control of Plasmodium falciparum malaria leads to a need for models of malaria epidemiology that provide realistic quantitative prediction of likely epidemiological outcomes of a [...] dynamics, limit the applicability of conventional deterministic malaria models. We use individual-based stochastic simulations of malaria epidemiology to predict the impacts of interventions on infection