Patterns of pesticide usage in agriculture in rural Tanzania call for integrating agricultural and public health practices in managing... (Publications)
and malaria vector control, poor pesticide management practices and low-levels of awareness among farmers and pesticides retailers might enhance the selection of insecticide resistance in malaria vectors
PfMAP-2 is essential for male gametogenesis in the malaria parasite<em> Plasmodium falciparum</em> (Publications)
In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alternating [...] induction of axoneme motility. However, in P. falciparum, causing the most severe form of human malaria, PfMAP-2 was suggested to be essential for asexual proliferation indicating distinct functions for
Correction to: Methods and indicators for measuring patterns of human exposure to malaria vectors (Publications)
An amendment to this paper has been published and can be accessed via the original article.
Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults (Publications)
(Pf) sporozoites (PfSPZ Vaccine) and protective efficacy assessed by homologous controlled human malaria infection (CHMI). Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf [...] first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2,239 functionally diverse Pf proteins
Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria (Publications)
framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator. We demonstrate our approach by optimizing over a high-dimensional parameter [...] a portfolio of multiple fitting objectives built from datasets capturing the natural history of malaria transmission and disease progression. Our approach quickly outperforms previous calibrations, yielding
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites (Publications)
t protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however [...] function has not been investigated in gametocytes, the sexual blood stage forms that are essential for malaria transmission. By studying a conditional PfPKAc knockdown (cKD) mutant, we confirm the essential role
Effect of interventions to reduce malaria incidence among military personnel on active duty: study protocol for a cluster randomised controlled trial... (Publications)
studies assessing the impact on malaria infection. This study will estimate the protective efficacy of treated uniforms and DEET insect repellent on the incidence of malaria infection among military personnel [...] placebo-controlled trial is planned to evaluate the effectiveness of the interventions on preventing malaria infections in soldiers on active duty at Mgambo National Service Camp in Tanga, Tanzania. The arms [...] untreated uniforms with placebo lotion. The primary outcome is the...
Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S (Publications)
ns. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed
Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea (Publications)
BACKGROUND: Malaria transmission is currently resurging in Papua New Guinea (PNG). In addition to intervention coverage, social and cultural factors influence changes in epidemiology of malaria in PNG. This [...] in relation to current malaria control efforts. METHODS: A mixed-method design was used in 2 sites in PNG. In-depth interviews, focus group discussions, cross-sectional malaria indicator survey, and population [...] d in adult men. CONCLUSIONS: Our findings highlight the potential of...
New methodological approaches to monitor long lasting insecticidal nets (LLINs) durability for sustained malaria control (Publications)
Long lasting insecticidal nets (LLINs) are the current primary vector control measure to prevent malaria transmission. They function by inhibiting mosquitoes from blood feeding and also killing mosquitoes [...] Resistance) and 2) Holed Net project. The ABCDR project aimed at understanding of bednet durability in malaria endemic countries and factors affecting bednet durability with the main focus of using that information