Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa (Publications)
of the age- and season- dependence of malaria mortality is an important prerequisite for epidemiologic models of malaria immunity. However, most studies of malaria mortality have aggregated their results [...] stable endemic Plasmodium falciparum malaria. We use verbal autopsies (VAs) to estimate the proportion of deaths by age group due to malaria, and thus calculate malaria-specific mortality rates for each site [...] attributed to malaria. The overall age patterns of malaria mortality were...
Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa (Publications)
of the age- and season- dependence of malaria mortality is an important prerequisite for epidemiologic models of malaria immunity. However, most studies of malaria mortality have aggregated their results [...] stable endemic Plasmodium falciparum malaria. We use verbal autopsies (VAs) to estimate the proportion of deaths by age group due to malaria, and thus calculate malaria-specific mortality rates for each site [...] attributed to malaria. The overall age patterns of malaria mortality were...
Human unconventional T cells in <em>Plasmodium falciparum</em> infection (Publications)
field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less [...] tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement [...] Malaria is an old scourge of humankind and has a large negative impact...
Human unconventional T cells in <em>Plasmodium falciparum</em> infection (Publications)
field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less [...] tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement [...] Malaria is an old scourge of humankind and has a large negative impact...
MMC elimination costing (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/mmc-elimination-costing
of malaria elimination interventions. This includes surveillance and a range of targeted and focal malaria elimination interventions when added incrementally to current levels of routine malaria control [...] model developed based on data collected by current malaria elimination trials, (2) estimates of costs, effectiveness, and cost-effectiveness of malaria elimination interventions and strategies for a number [...] number of policy relevant scenarios simulated with a simulation model of malar...
Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/multi-scale-mathematical-modelling-of-parasite-drug-and-vaccine-interactions-optimising-public-health-and-disease-elimination-strategies
are best able to reduce and halt malaria transmission. Mathematical modelling can help understand malaria dynamics and interactions between malaria tools and the malaria parasite, human and mosquito hosts [...] been made over the last decades in controlling malaria. From 2000 to 2015 scale-up of control and curative interventions enabled a 60% reduction in malaria death rates and a 40% reduction in rate of clinical [...] disease. Despite these gains, we face significant challenges if we are to...
Corine Karema (People)
https://www.swisstph.ch/fr/staff/profile/people/corine-karema
of malaria control strategies, policies and research, which has guided most of the evidence-based malaria control interventions in Rwanda. She has designed and led the impact evaluation of malaria control [...] former Director of the Rwanda National Malaria Control Programme (NMCP) where she served in this role for 10 years. From 2011 to May 2016, she was also the head of Malaria & Other Parasitic Diseases (Neglected [...] Corine was also the Co–chair of the East African Roll Back Malaria...
A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar (Publications)
BACKGROUND: Intensive malaria control interventions in the United Republic of Tanzania have contributed to reductions in malaria prevalence. Given that malaria control remains reliant upon continued use [...] perceived risk of malaria had decreased among the respondents, and malaria control interventions were credited for the decline. Participants cited reductions in both the severity of malaria and in their perceived [...] perceived susceptibility to malaria. However, malaria was still...
A good night's sleep and the habit of net use: perceptions of risk and reasons for bed net use in Bukoba and Zanzibar (Publications)
BACKGROUND: Intensive malaria control interventions in the United Republic of Tanzania have contributed to reductions in malaria prevalence. Given that malaria control remains reliant upon continued use [...] perceived risk of malaria had decreased among the respondents, and malaria control interventions were credited for the decline. Participants cited reductions in both the severity of malaria and in their perceived [...] perceived susceptibility to malaria. However, malaria was still...
Antigens released at schizont burst stimulate <em>Plasmodium falciparum</em>-specific CD4+ T cells from non-exposed donors: potential for... (Publications)
individuals can be stimulated by malaria parasites. Here, we show that nine from 11 blood samples, naturally infected with malaria parasites, could stimulate proliferation of a malaria-specific T cell clone derived [...] the T cell response of naive donors to malaria parasites, processing of parasite antigens is blocked by chloroquine and monensin, and activation of 36 of 41 malaria-specific clones tested was restricted [...] activation of cross-reactive memory T cells by malaria parasites...