The economic cost to households of childhood malaria in Papua New Guinea: a focus on intra-country variation (Publications)
BACKGROUND We compare direct and indirect household costs associated with malaria treatment for children
Effectiveness of artemether/lumefantrine for the treatment of uncomplicated <em>Plasmodium vivax</em> and <em>P. falciparum</em> malaria in young... (Publications)
uncomplicated Plasmodium falciparum (Pf) malaria, while chloroquine is still widely used for non-Pf infections. A common treatment for both vivax and falciparum malaria would be welcome.Methods. A longitudinal [...] had an infection confirmed by blood slide (BS) examination. Of these, 594 Pv and 332 Pf clinical malaria cases were included in the primary effectiveness analysis. Clinical treatment failure rates at 7 [...] 7, 28 and 42 days were 0.2%, 2.2% and 12.0% for Pv and 0.3%, 1.2% and 3.6%...
Reproduction numbers in malaria and their implications (Publications)
important for analyzing the effects of interventions against malaria. This has importance for both formal modeling of malaria and for planning malaria intervention strategies in the field [...] The malariologist Lewis Wendell Hackett famously observed that, "Like chess, (malaria) is played with a few pieces, but is capable of an infinite variety of situations". This paper discusses one such piece
Structural and functional characterisation of the toll like receptor 9 of <em>Aotus nancymaae</em>, a non-human primate model for malaria vaccine... (Publications)
In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between [...] sequence conservation of Aona-TLR-9 reinforces the suitability of A. nancymaae as animal model for malaria subunit vaccine development
Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism [...] metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria