Indigenous <em>Plasmodium malariae</em> infection in an endemic population at the Thai-Myanmar border (Publications)
Plasmodium malariae is a neglected malaria parasite. It has wide geographic distribution and, although often associated with mild malaria, is linked to a high burden of anemia and nephrotic syndromes. [...] participants, two were found to be infected with P. malariae. One had an infection that led to acute malaria, but the other was positive for P. malariae at multiple visits during the study and apparently had [...] explain how P. malariae has been able to thrive at very low prevalence and...
Till Voss (People)
https://www.swisstph.ch/fr/staff/profile/people/till-voss
Till Voss, Unit Head, Malaria Gene Regulation (MPI) Till Voss is the Deputy Head of the Medical Parasitology and Infection Biology Department and leads the Malaria Gene Regulation Unit at Swiss TPH. He [...] that drive antigenic variation and sexual commitment in malaria parasites. Further activities include studies on gametocyte biology and malaria transmission-blocking drug discovery. Voss obtained his MSc
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG [...] significantly different between the children who developed severe malaria and those who remained healthy during an observation period of two malaria transmission seasons. However, elevated levels of IgG1 in relation [...] protection from severe malaria (P = 0.02). Conversely, elevated levels...
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG [...] significantly different between the children who developed severe malaria and those who remained healthy during an observation period of two malaria transmission seasons. However, elevated levels of IgG1 in relation [...] protection from severe malaria (P = 0.02). Conversely, elevated levels...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
Manuel Hetzel (People)
https://www.swisstph.ch/fr/staff/profile/people/manuel-hetzel
research, and impact evaluations, with a focus on malaria. Dr. Hetzel’s current work includes investigating and improving the effectiveness of malaria control measures, such as vector control, case management [...] artesunate as pre-referral treatment of severe malaria in children in rural DR Congo, Nigeria and Uganda and conducted studies on the effectiveness of malaria reactive case detection in Zanzibar (Tanzania) [...] (Tanzania). Since 2008, he has been supporting the National Malaria...
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resistance in malaria vectors. The aim of this study [...] resistance in malaria vectors, while people's knowledge about insecticide resistance was limited. There is a need to raise awareness in communities about the presence of resistance in malaria vectors and [...] study was to investigate KAPB related to insecticide resistance in malaria...
Reduction in the proportion of fevers associated with <em>Plasmodium falciparum</em> parasitaemia in Africa: a systematic review (Publications)
BACKGROUND: Malaria is almost invariably ranked as the leading cause of morbidity and mortality in Africa. There is growing evidence of a decline in malaria transmission, morbidity and mortality over the [...] presenting with a syndrome of 'presumptive malaria', 3) numerators (number of parasitologically confirmed cases) and denominators (total number of presumptive malaria cases) available, 4) good quality microscopy [...] However, there is still doubt whether this decline is reflected in a...