Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
homogeneous transmission used in mathematical transmission models for malaria. In the present study an individual-based mathematical malaria transmission model that incorporates multiple parasite clones, variable [...] prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected with multiple parasite clones [...] As malaria is being pushed back on many frontiers and global case...
PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria in malaria-naïve [...] underexplored, target for vaccine-induced antibodies in malaria pre-exposed volunteers. FUNDING: This work was supported by the Equatorial Guinea Malaria Vaccine Initiative (EGMVI), the Clinical Trial Platform [...] , we profiled IgG and IgM responses to PfSPZ Vaccine and subsequent...
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Phase 1 study in Tanzania to evaluate the safety and immunogenicity of BSPZV1 - a vaccine against Plasmodium falciparum sporozoite (PfSPZ) (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/phase-1-study-in-tanzania-to-evaluate-the-safety-and-immunogenicity-of-bspzv1-a-vaccine-against-plasmodium-falciparum-sporozoite-pfspz
Vaccine) in Tanzanian adults Malaria is one of the most severe diseases in tropical countries. During the last decade, great effort has led to success in controlling malaria transmission, morbidity and [...] and mortality. Nevertheless, still around 660 000 people die due to malaria infection per year. For further reduction and, ideally, to gain elimination of this of this burden, a vaccine is crucial. Since [...] well as induction of immune response. Afterwards, protective efficacy is tested by...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately become part of...
Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of <em>Plasmodium falciparum</em>: a feasibility study (Publications)
Genomic epidemiology holds promise for malaria control and elimination efforts, for example by informing on Plasmodium falciparum genetic diversity and prevalence of mutations conferring anti-malarial [...] drug resistance. Limited sequencing infrastructure in many malaria-endemic areas prevents the rapid generation of genomic data. To address these issues, we developed and validated assays for P. falciparum [...] resistance markers. We developed a bioinformatics workflow that allows genotyping...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
