Molecular monitoring of <em>Plasmodium falciparum</em> resistance to artemisinin in Tanzania (Publications)
combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa. However, their long-term usefulness in these high [...] Tanzania, supporting the Ministry of Health's decision to adopt artemether+lumefantrine as first-line malaria treatment. The findings recommend further studies to assess PfATPase6 mutations in sentinel sites
Molecular monitoring of <em>Plasmodium falciparum</em> resistance to artemisinin in Tanzania (Publications)
combination therapies (ACTs) are recommended for use against uncomplicated malaria in areas of multi-drug resistant malaria, such as sub-Saharan Africa. However, their long-term usefulness in these high [...] Tanzania, supporting the Ministry of Health's decision to adopt artemether+lumefantrine as first-line malaria treatment. The findings recommend further studies to assess PfATPase6 mutations in sentinel sites
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks <em>Plasmodium falciparum</em> transmission to Anopheles... (Publications)
The global malaria agenda has undergone a reorientation from control of clinical cases to entirely eradicating malaria. For that purpose, a key objective is blocking transmission of malaria parasites from
Identification and validation of a gene causing cross-resistance between insecticide classes in <em>Anopheles gambiae</em> from Ghana (Publications)
reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles [...] simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from
Vector Modelling - AnophelesModel R Package (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/vector-modelling-anophelesmodel-r-package
for the entomological and vector control components of more complex models of malaria transmission dynamics such as OpenMalaria . Mosquito distribution and human behavior vary across geographical settings [...] Package to interface mosquito bionomics, human exposure and intervention effects with models of malaria intervention impact. The package contains an in-built entomological model of the mosquito feeding [...] n parameters. The different types of data have been extracted from field studies...
Analysis of <em>Plasmodium falciparum</em> var genes expressed in children from Papua New Guinea (Publications)
sequences was detected in symptomatic malaria, and a subgroup of frequently encountered var genes with complex head structure seems to be associated with severe malaria. A subset of var group C genes was [...] variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we hypothesized that a restricted PfEMP1 repertoire [...] children. METHODS: var messenger RNA was isolated from 78 children with...
Analysis of <em>Plasmodium falciparum</em> var genes expressed in children from Papua New Guinea (Publications)
sequences was detected in symptomatic malaria, and a subgroup of frequently encountered var genes with complex head structure seems to be associated with severe malaria. A subset of var group C genes was [...] variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we hypothesized that a restricted PfEMP1 repertoire [...] children. METHODS: var messenger RNA was isolated from 78 children with...
Identification and validation of a gene causing cross-resistance between insecticide classes in <em>Anopheles gambiae</em> from Ghana (Publications)
reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary African malaria vector, Anopheles [...] simultaneously reduces the efficacy of two of the four classes of insecticide routinely used for malaria control. The gene-expression profile of a highly DDT-resistant population of A. gambiae s.s. from
<em>Plasmodium falciparum</em> genetic diversity in western Kenya highlands (Publications)
microsatellite loci and two antigen loci. Malaria in highland areas is unstable and epidemic whereas malaria in lowland areas is endemic. Transmission intensity and malaria prevalence are substantially lower
<em>Plasmodium falciparum</em> infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy... (Publications)
ed erythrocytes are thought to play a role in the development of naturally acquired immunity to malaria. It has been suggested that children gradually acquire immunity through the piecemeal acquisition [...] over several years of exposure. However, in a cross-sectional survey of Kenyan children before the malaria-transmission season, the proportion of children with antibodies recognizing randomly sampled VSAs [...] data from a prospective study of VSA antibodies in a group of children who...
