Effects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets: a modelling study (Publications)
were used. The epidemiological models, implemented in OpenMalaria, were employed to study the impact of a single mass distribution of LLINs on malaria, both in terms of episodes prevented during the effective [...] BACKGROUND: The effectiveness of insecticide-treated nets in preventing malaria is threatened by developing resistance against pyrethroids. Little is known about how strongly this affects the effectiveness [...] levels of mortality in World Health Organization susceptibility tests,...
Do holes in long-lasting insecticidal nets compromise their efficacy against pyrethroid resistant <em>Anopheles gambiae</em> and <em>Culex... (Publications)
BACKGROUND: Resistance of malaria vectors to pyrethroids threatens the effectiveness of long-lasting insecticidal nets (LLINs) as a tool for malaria control. Recent experimental hut and observational studies [...] round holes. This study examines whether there is a threshold above which LLINs no longer reduce malaria transmission. METHODS: Intact and artificially-holed LLINs under three months old and untreated nets [...] evaluated in terms of protection against blood feeding, insecticidal...
Dietary diversity in primary schoolchildren of south-central Côte d'Ivoire and risk factors for non-communicable diseases (Publications)
prediabetes and malaria infection, as well as medium and high DDS. Overweight was associated with malaria infection and moderate anaemia. CONCLUSION: Overweight, prediabetes, low HDL-C, malaria, and anaemia [...] the primary caretaker according to the guideline of Food and Agriculture Organization. Anaemia, malaria, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood [...] health in Taabo. Our findings highlight interactions between infectious...
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
Nicolas Brancucci (People)
https://www.swisstph.ch/fr/staff/profile/people/nicolas-brancucci
TPH to establish new drug screening approaches and to search for malaria transmission-blocking drugs. Since 2020, he is leading the “Malaria Host Interactions” research unit at the Swiss THP and holds a [...] Brancucci is a parasitologist particularly interested in studying molecular interactions between malaria parasites and their human host cells. In current projects, his team studies nutrient sensing and
Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children (Publications)
RTS,S/AS01(E), the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary [...] from 709 children and infants after RTS,S/AS01(E) antigen stimulation, and their associations with malaria risk and antibodies one month post-booster and one year later were assessed. IL-2, IFN-γ, IL-17, [...] circumsporozoite protein (CSP) remained higher after one year. IL-2 was...
The effect of novel mosquito bite prevention tools on <em>Anopheles minimus</em> landing and key secondary endpoints: semi-field evaluations in... (Publications)
Greater Mekong Subregion (GMS) aims to eliminate all human malaria by 2030 and is making substantial progress toward this goal, with malaria increasingly confined to forest foci. These transmission foci [...] ions of the World Health Organization (WHO) on malaria elimination states that small population groups which constitute a large proportion of the malaria transmission reservoir should benefit from targeted [...] targeted strategies to reduce transmission overall. These population groups are...
Safety and differential antibody and T-cell responses to <em>Plasmodium falciparum</em> sporozoite vaccine by age in Tanzanian adults, adolescents,... (Publications)
2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria((R)) PfSPZ Vaccine, composed [...] (SPZ) has been well tolerated and safe in malaria-naive and experienced adults in the United States and Mali and protective against controlled human malaria infection with Pf in the United States and
Feasibility and acceptability of insecticide-treated plastic sheeting (ITPS) for vector control in Papua New Guinea (Publications)
sheeting (ITPS) as a malaria control intervention in Papua New Guinea (PNG). METHODS: ZeroVector(R) ITPS was installed in 40 homes across four study sites representing a cross section of malaria transmission risk [...] potential application of ITPS in the national malaria control programme. The positive study findings suggest a longer-term evaluation of this promising malaria control intervention warrants consideration