Health facility-based data on women receiving sulphadoxine-pyrimethamine during pregnancy in Tanzania: lessons to learn from a cross-sectional survey... (Publications)
data on women receiving sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) was carried out at antenatal care clinics in Mkuranga and Mufindi districts [...] system (HMIS) registers, interviews with health-care workers (HWs) and district and national level malaria control program managers corroborated by inter-temporal assessment through observations at HF levels [...] measures are urgently needed to accommodate data on new interventions and...
Eastern Africa, Madagascar and Indian Ocean Islands (Publications)
Travellers in East Africa are potentially exposed to malaria, arboviral infections, schistosomiasis, African sleeping sickness (African trypanosomiasis) and many other infectious diseases. Exposure determines [...] presenting with an acute febrile illness may have acquired an infection specific to the region (e.g. malaria, African tick bite fever) or common worldwide (e.g. influenza, EBV). East Africa is the second most [...] of the region. Of concern are recent reports of emerging artemisinin...
The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis (Publications)
vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs [...] with unknown G6PD status from two different countries were prescribed primaquine as per national malaria program guidelines. During treatment both patients presented to the clinic with symptoms of anaemia
Molecular epidemiology and seroprevalence in asymptomatic <em>Plasmodium falciparum</em> infections of Malagasy pregnant women in the highlands (Publications)
BACKGROUND: Malaria epidemiology in Madagascar is classified into four different areas, ranging from unstable seasonal transmission in the highlands to hyperendemic perennial transmission areas in the [...] the costal level. Most malaria studies in Madagascar are focused on symptomatic children. However, because of the low transmission in some areas with correspondingly low level of semi-immunity, adults are [...] genetic epidemiology of malarial infections in pregnant women in order to provide...
A review of the frequencies of <em>Plasmodium falciparum</em> Kelch 13 artemisinin resistance mutations in Africa (Publications)
failure, except for Rwanda. These mutations present a threat to malaria control across the continent, since the greatest burden of malaria remains in Africa. A rise in the frequency of these mutations and [...] Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool for monitoring AR in malaria endemic countries. Molecular Pfk13 surveillance revealed the resistance foci in the Greater Mekong [...] and their spread would reverse the gains made in the reduction of malar...
Emergence of FY*A(null) in a <em>Plasmodium vivax</em>-endemic region of Papua New Guinea (Publications)
Human genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition cha [...] demonstrated that alpha(+)-thalassemia is associated with increased susceptibility to uncomplicated malaria among young children. It is further proposed that alpha(+)-thalassemia may facilitate so- called [...] vivax infection to act later in life as a "natural vaccine" against severe...
Spatial mapping and prediction of <em>Plasmodium falciparum</em> infection risk among school-aged children in Côte d'Ivoire (Publications)
school-aged children in Cote d'Ivoire represent the most up-to-date malaria risk maps. These tools can be used for spatial targeting of malaria control interventions. [...] BACKGROUND: In Cote d'Ivoire, malaria remains a major public health issue, and thus a priority to be tackled. The aim of this study was to identify spatially explicit indicators of Plasmodium falciparum [...] ownership and household characteristics. Children were interviewed for preventive measures against malaria....
Recalculating the net use gap: a multi-country comparison of ITN use versus ITN access (Publications)
treated nets is widely recognized as one of the main interventions to prevent malaria and high use rates are a central goal of malaria programs. The gap between household ownership of at least one ITN and population [...] within the household' as now recommended by Roll Back Malaria and the World Health Organization. Data from 41 Demographic Health Surveys (DHS) and Malaria Indicator Surveys (MIS) (2005-2012) in sub-Saharan
Leptospira seroprevalence and risk factors in health centre patients in Hoima District, Western Uganda (Publications)
consented participants. Overall, 69% reported having fever in the past year, with 49% reporting malaria, 14% malaria relapse, 6% typhoid fever, 3% brucellosis, and 0% leptospirosis. We tested sera by microscopic [...] Nigeria (serogroup Pyrogenes). Probable recent leptospirosis was associated with having self-reported malaria within the past year (p = 0.048). Higher risk activities included skinning cattle (n = 6) with 12 [...] serogroup). Leptospirosis should be a diagnostic consideration in...
Costs and effects of the Tanzanian national voucher scheme for insecticide-treated nets (Publications)
approach in Tanzania has been to deliver a targeted subsidy for those most vulnerable to the effects of malaria while at the same time providing support to the development of the commercial ITN distribution system [...] system. In October 2004, with funds from the Global Fund to Fight AIDS Tuberculosis and Malaria, the government launched the Tanzania National Voucher Scheme (TNVS), a nationwide discounted voucher scheme [...] (and therefore nets delivered) and treated nets years. Estimates were...