Leptospira seroprevalence and risk factors in health centre patients in Hoima District, Western Uganda (Publications)
consented participants. Overall, 69% reported having fever in the past year, with 49% reporting malaria, 14% malaria relapse, 6% typhoid fever, 3% brucellosis, and 0% leptospirosis. We tested sera by microscopic [...] Nigeria (serogroup Pyrogenes). Probable recent leptospirosis was associated with having self-reported malaria within the past year (p = 0.048). Higher risk activities included skinning cattle (n = 6) with 12 [...] serogroup). Leptospirosis should be a diagnostic consideration in...
Spatial mapping and prediction of <em>Plasmodium falciparum</em> infection risk among school-aged children in Côte d'Ivoire (Publications)
school-aged children in Cote d'Ivoire represent the most up-to-date malaria risk maps. These tools can be used for spatial targeting of malaria control interventions. [...] BACKGROUND: In Cote d'Ivoire, malaria remains a major public health issue, and thus a priority to be tackled. The aim of this study was to identify spatially explicit indicators of Plasmodium falciparum [...] ownership and household characteristics. Children were interviewed for preventive measures against malaria....
Comparative efficacy of Vector Guard® to Olyset® Plus insecticide-treated nets against strongly pyrethroid-resistant <em>Anopheles arabiensis</em> in... (Publications)
promising pyrethroid–PBO ITN for the control of resistant malaria vectors. The addition of Vector Guard® to the class of pyrethroid–PBO ITNs will enable malaria control programs to select cost-effective ITNs, improving [...] Introduction: The resistance of malaria vectors to pyrethroids has compromised the efficacy of pyrethroid insecticide-treated nets (ITNs). In response, ITNs with pyrethroids and piperonyl butoxide (PBO) [...] conducted to evaluate Vector Guard® relative to Olyset® Plus (a...
Analysis of diagnostic findings from the European mobile laboratory in Gueckedou, Guinea, March 2014 through March 2015 (Publications)
2015. METHODS: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:
Analysis of diagnostic findings from the European mobile laboratory in Gueckedou, Guinea, March 2014 through March 2015 (Publications)
2015. METHODS: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS:
Next generation chemiluminescent probes for antimalarial drug discovery (Publications)
Malaria is caused by parasites of the Plasmodium genus and remains one of the most pressing human health problems. The spread of parasites resistant to or partially resistant to single or multiple drugs [...] frontline antimalarial artemisinin and its derivatives, poses a serious threat to current and future malaria control efforts. In vitro drug assays are important for identifying new antimalarial compounds and [...] detection limit of less than 100 parasites of the presented biosensor system...
Artemisinins and synthetic trioxolanes in the treatment of helminth infections (Publications)
following recommended malaria treatment schedules, found an effect against schistosomiasis. SUMMARY: Artemisinin-based combination therapies are increasingly deployed against malaria, and hence there is [...] that artemisinin-based combination therapy might have on trematode infections in settings where malaria and helminthiases are co-endemic. RECENT FINDINGS: The artemisinins and synthetic trioxolanes possess
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Comparison of analytical methods for the evaluation of antibody responses against epitopes of polymorphic protein antigens (Publications)
Surface exposed protein antigens of the malaria parasite Plasmodium falciparum frequently harbor multiple dimorphic amino acid positions. These are associated with parasite immune evasion and represent [...] the humoral immune response against a semiconserved sequence (YX(44)LFX(47)KEKMX(52)L) of the key malaria blood stage vaccine candidate merozoite surface protein-1 (MSP-1). Monoclonal antibodies (mAbs) raised [...] MSP-1(43-53) variant sequences. When used for the evaluation of humoral...
Pan-Africa Network for Genomic Surveillance of Poverty Related Diseases and Emerging Pathogens (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/pan-africa-network-for-genomic-surveillance-of-poverty-related-diseases-and-emerging-pathogens
The main objective of the PANGenS project is to use genomic epidemiology of tuberculosis, malaria and emerging and re-emerging pathogens in Africa to better understand disease etiology, dynamics of disease [...] will aid infectious disease monitoring, and genomic surveillance will detect drug-resistant TB and malaria parasites. To achieve this, PANGenS will develop genomic epidemiology capacity across Africa by [...] components, from wet lab to bioinformatics, and to establish proof-of-concept...