Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves... (Publications)
falciparum NODscidIL2Rgammanull mouse malaria infection model. The observation of atypical dose-response curves when some compounds were tested against multidrug resistant malaria parasite strains guided the o
Quality control of long-lasting insecticidal nets: are we neglecting it? (Publications)
long-lasting insecticidal nets (LLINs) for malaria control have been delivered to recipient countries. LLINs are the largest single item in the global malaria control budget. To be eligible for donor-funded
WHO antimalarial trial guidelines: good science, bad news? (Publications)
infections arising during the several-week follow-up period in drug trials. Genetic profiling of malaria infections can guide this decision but is notoriously difficult in practice. Previous World Health [...] more accurate but will likely rise twofold due to better detection of treatment failures, and the malaria community needs to anticipate and prepare for potentially large increases in estimated failure rates
Case report: Diagnostic challenges in the detection of a mixed <em>Plasmodium vivax/ovale</em> infection in a non-endemic setting (Publications)
In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the [...] This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity [...] infection remained undetected by microscopy. The introduction of PCR has opened up new possibilities in malaria diagnosis and research.
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity [...] infection remained undetected by microscopy. The introduction of PCR has opened up new possibilities in malaria diagnosis and research.
WHO antimalarial trial guidelines: good science, bad news? (Publications)
infections arising during the several-week follow-up period in drug trials. Genetic profiling of malaria infections can guide this decision but is notoriously difficult in practice. Previous World Health [...] more accurate but will likely rise twofold due to better detection of treatment failures, and the malaria community needs to anticipate and prepare for potentially large increases in estimated failure rates
Case report: Diagnostic challenges in the detection of a mixed <em>Plasmodium vivax/ovale</em> infection in a non-endemic setting (Publications)
In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the [...] This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug... (Publications)
inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective. We have previously shown that the di-amino [...] highly PM-resistant Plasmodium falciparum V1S strain, suggesting that QN254 could be used to treat malaria in regions with a high prevalence of antifolate resistance. Here, we further demonstrate that QN254
Indifferent to disease: a qualitative investigation of the reasons why some Papua New Guineans who own mosquito nets choose not to use them (Publications)
regarding malaria transmission pathways or the utility of mosquito nets did not appear to underlie this indifference. Rather, the indifference appeared to be rooted in a lack of fear of malaria infection [...] render individual mosquito net use as easy and as convenient as possible and to promote complementary malaria control strategies where appropriate