On a mission to block transmission (Publications)
falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
On a mission to block transmission (Publications)
falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
Etiology of anemia among infants, school-aged children, and young non-pregnant women in different settings of south-central Côte d'Ivoire (Publications)
samples were subjected to standardized quality-controlled methods. We found high prevalence of anemia, malaria, inflammation, and deficiencies of iron, riboflavin, and vitamin A but low prevalence and intensities [...] factor for anemia in non-pregnant women. Our findings call for interventions to protect infants from malaria, improved intake of dietary iron, and given the importance of anemia of inflammation in school-aged
Multiplex assay for species identification and monitoring of insecticide resistance in <em>Anopheles punctulatus</em> group populations of Papua New... (Publications)
complex [eight cryptic species]) are principal vectors of malaria and filariasis in the Southwest Pacific. Given significant effort to reduce malaria and filariasis transmission through insecticide-treated
Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in <em>Plasmodium falciparum</em> (Publications)
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill [...] polymerization pathway and that can form the basis of future optimization efforts to develop a new malaria treatment.
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
Multiplexed ddPCR-amplicon sequencing reveals isolated <em>Plasmodium falciparum</em> populations amenable to local elimination in Zanzibar, Tanzania (Publications)
Zanzibar has made significant progress toward malaria elimination, but recent stagnation requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR)-based amplicon sequencing [...] genetic structure across the Zanzibar archipelago and provides actionable insights for prioritizing malaria elimination efforts.
Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles (Publications)
The 4-substituted 3-amino-1,2,5-oxadiazole 1 from the Malaria Box Project of the Medicines for Malaria Venture foundation shows very promising selectivity and in vitro activity against Plasmodium falciparum