Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in <em>Plasmodium falciparum</em> (Publications)
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill [...] polymerization pathway and that can form the basis of future optimization efforts to develop a new malaria treatment.
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
Luis Segura (People)
https://www.swisstph.ch/fr/staff/profile/people/luis-segura
by The Global Fund in the Americas, Africa, and South East Asia regions. He also has led a large malaria program in Equatorial Guinea, which in addition to communicational interventions, vector control [...] technical and logistic support to case management, included clinical trials of a sporozoite based malaria vaccine. His experience includes also operational research and monitoring of maternal-child and
Costing RTS,S introduction in Burkina Faso, Ghana, Kenya, Senegal, Tanzania, and Uganda: a generalizable approach drawing on publicly available data (Publications)
Recent results from the phase 3 trial of RTS,S/AS01 malaria vaccine show that the vaccine induced partial protection against clinical malaria in infants and children; given the high burden of the disease [...] disease it is currently considered for use in malaria endemic countries. To inform adoption decisions the paper proposes a generalizable methodology to estimate the cost of vaccine introduction using routinely
Human exposure to anopheline mosquitoes occurs primarily indoors, even for users of insecticide-treated nets in Luangwa Valley, south-east Zambia (Publications)
insecticidal products. We studied the human biting behaviour of the malaria vector Anopheles funestus Giles and the potential malaria vector Anopheles quadriannulatus Theobald in Luangwa valley, south-east [...] ABSTRACT: BACKGROUND: Current front line malaria vector control methods such as indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs), rely upon the preference of many primary vectors
Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania (Publications)
BACKGROUND: Insecticide-treated nets have proven efficacy as a malaria-control tool in Africa. However, the transition from efficacy to effectiveness cannot be taken for granted. We assessed coverage and [...] programme for insecticide-treated nets in two rural districts of southern Tanzania with high perennial malaria transmission. METHODS: Socially marketed insecticide-treated nets were introduced step-wise over [...] INTERPRETATION: Social marketing of insecticide-treated nets has great...
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against <em>Schistosoma haematobium</em>: randomized,... (Publications)
Schistosoma who were treated with a mefloquine-artesunate combination against malaria might have a dual benefit: clearance of malaria parasitemia and reduction of schistosomiasis-related morbidity. CLINICAL [...] and praziquantel (40 mg/kg) against Schistosoma haematobium. The effects on Schistosoma mansoni, malaria parasitemia, soil-transmitted helminths, and intestinal protozoa were also determined. RESULTS: A
Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania (Publications)
BACKGROUND: Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends [...] of fever onset. In neither of the HDSS site was age, sex, socio-economic status or seasonality of malaria found to be significantly correlated with timely access. CONCLUSION: Timely access to authorized [...] major bottle neck and new more innovative interventions are needed to raise...
The practical importance of permanent and semipermanent habitats for controlling aquatic stages of <em>Anopheles gambiae</em> <em>sensu lato</em>... (Publications)
aquatic-stage Anopheles is one of the oldest and most historically successful interventions to prevent malaria, but it has seen little application in Africa. Consequently, the ecology of immature afrotropical [...] examine the relative importance and availability of different larval habitats in an area of perennial malaria transmission in preparation for a pilot-scale larval control programme. The study was conducted in [...] types, regardless of permanence. All potential breeding sites need to...
Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania (Publications)
BACKGROUND: Insecticide-treated nets have proven efficacy as a malaria-control tool in Africa. However, the transition from efficacy to effectiveness cannot be taken for granted. We assessed coverage and [...] programme for insecticide-treated nets in two rural districts of southern Tanzania with high perennial malaria transmission. METHODS: Socially marketed insecticide-treated nets were introduced step-wise over [...] INTERPRETATION: Social marketing of insecticide-treated nets has great...