The practical importance of permanent and semipermanent habitats for controlling aquatic stages of <em>Anopheles gambiae</em> <em>sensu lato</em>... (Publications)
aquatic-stage Anopheles is one of the oldest and most historically successful interventions to prevent malaria, but it has seen little application in Africa. Consequently, the ecology of immature afrotropical [...] examine the relative importance and availability of different larval habitats in an area of perennial malaria transmission in preparation for a pilot-scale larval control programme. The study was conducted in [...] types, regardless of permanence. All potential breeding sites need to...
Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used? (Publications)
(ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the global burden of malaria in recent years. While the [...] ITN for 2 people did not exceed 60% at the national level in any survey, except in Uganda's 2014 Malaria Indicator Survey (MIS). At 80% population ITN access, the expected proportion of households with [...] success of an ITN distribution programme. Under current ITN distribution...
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have been [...] six months after the mass distribution. Descriptive statistics were used to measure changes in key malaria household indicators. LLIN ownership and use were compared between delivery strategies. Univariate [...] have a significant impact on LLIN use (69.6% [95% CI 63.1-75.5%] versus 65.7%...
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have been [...] six months after the mass distribution. Descriptive statistics were used to measure changes in key malaria household indicators. LLIN ownership and use were compared between delivery strategies. Univariate [...] have a significant impact on LLIN use (69.6% [95% CI 63.1-75.5%] versus 65.7%...
Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used? (Publications)
(ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the global burden of malaria in recent years. While the [...] ITN for 2 people did not exceed 60% at the national level in any survey, except in Uganda's 2014 Malaria Indicator Survey (MIS). At 80% population ITN access, the expected proportion of households with [...] success of an ITN distribution programme. Under current ITN distribution...
Assessment of the factors affecting emergence and spread of artemisinin resistance in Rwanda (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/assessment-of-the-factors-affecting-emergence-and-spread-of-artemisinin-resistance-in-rwanda
districts without artemisinin resistance. We will recruit malaria patients (uncomplicated and severe) and asymptomatic carriers with a positive malaria rapid diagnostic test (RDT), over a two-year period at [...] Background: Malaria is a major public health problem globally and resistance to most widely used drugs impedes its control. Artemisinin resistance has emerged and spread in the Greater Mekong Sub region [...] factors that have led to the emergence of artemisinin resistance in Rwanda ยท...
Plasmodium vivax Transmission Model (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/plasmodium-vivax-transmission-model
parasite is dominant. This compartmental model accounts specifically for the liver stages of P. vivax malaria and it has recently been refined to include imported infections as well as treatment of blood and/or [...] data on reported local and imported cases, and it can be used to simulate the expected impact of malaria treatment schemes, vector control strategies, reactive interventions or mass drug administration
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
isolates and lab-raised drug-resistant strains of Pf. It was efficacious in the humanized NSG mouse malaria infection model at a single oral dose of 32 mg/kg. This compound was nonteratogenic in the zebrafish [...] human dose, indicating that this series has the potential to deliver a preclinical candidate for malaria.