Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy (Publications)
pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency,
Eric Huber (People)
https://www.swisstph.ch/fr/staff/profile/people/eric-huber
monitoring of trials, mainly in resource-limited countries, focusing on neglected diseases such as malaria, tuberculosis and helminth infections. Through this work he has gained extensive experience in the
Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)
mammalian (L6) cells. Three representative compounds were selected for evaluation in a rodent model of malaria infection, and the best compound showed improved ability to decrease parasitaemia and a slight increase
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institut and risks for Switzerland (Publications)
This overview presents the Swiss Tropical Institute's (STI) activities on vector-borne diseases (malaria, trypanosomosis, and leishmaniosis in humans and tick-borne diseases in livestock), describes the
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the
Declining burden of <em>Plasmodium vivax</em> in a population in northwestern Thailand from 1995 to 2016 before comprehensive primaquine prescription... (Publications)
and artemisinin-based therapy, species-specific diagnostics, and bed net usage all of which reduce malaria transmission but not P. vivax relapse. In the absence of widespread primaquine use for radical cure
Composition and stage dynamics of mitochondrial complexes in<em> Plasmodium falciparum</em> (Publications)
organisms, which only represent a fraction of eukaryotic diversity. The unusual mitochondrion of malaria parasites is a validated drug target but remains poorly understood. Here, we apply complexome profiling
Translation of liver stage activity of M5717, a <em>Plasmodium</em> elongation factor 2 inhibitor: from bench to bedside (Publications)
stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. METHODS: M5717, a Plasmodium elongation factor 2 inhibitor, was
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity (Publications)
s and several of their esters have shown promising activity against the causative organisms for malaria and sleeping sickness. The base-catalyzed epimerization of the alcohols was carried out by different
Costs and cost-effectiveness of <em>Plasmodium vivax </em>control (Publications)
The continued success of efforts to reduce the global malaria burden will require sustained funding for interventions specifically targeting Plasmodium vivax The optimal use of limited financial resources