Evidence that <em>Plasmodium falciparum</em> chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing... (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation through allelic exclusion and variant expression of surface proteins encoded by the var gene family. Regulation of var genes is
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of
Detection of pathogens of acute febrile illness using polymerase chain reaction from dried blood spots (Publications)
1% specificity against the whole blood qPCR cutoff of 21 that has been previously suggested for malaria diagnosis. For other pathogens investigated, DBS testing yielded a sensitivity of only 8.5% but a
Additional blood meals increase sporozoite infection in <em>Anopheles</em> mosquitoes but not <em>Plasmodium falciparum</em> genetic diversity (Publications)
multiple blood meals on the number of P. falciparum genotypes developing from polyclonal natural human malaria infections (field-isolates) remains unexplored. Here, we experimentally infect An. gambiae with P
Pyrethroid and etofenprox resistance in <em>Anopheles gambiae </em>and <em>Anopheles coluzzii </em>from vegetable farms in Yaounde, Cameroon:... (Publications)
Previous studies have indicated widespread insecticide resistance in malaria vector populations from Cameroon. However, the intensity of this resistance and underlying mechanisms are poorly known. Therefore
The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes (Publications)
vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE-formulated peptide was
Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439 (Publications)
OZ439 is a potent synthetic ozonide evaluated for the treatment of uncomplicated malaria. The metabolite profile of OZ439 was characterized in vitro using human liver microsomes combined with LC/MS-MS
Differential infectivity of Plasmodium for mosquitoes (Publications)
The four human malarias - Plasmodium falciparum, P. vivax, P. ovale and P. malariaecan - canonly be transmitted by mosquitoes of the genus Anopheles, although not all species (nor all strains) of these
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate... (Publications)
DHODH inhibitors have great potential for use in prophylaxis, which represents an unmet need in the malaria drug discovery portfolio for endemic countries, particularly in areas of high transmission in Africa
Klaus Reither (People)
https://www.swisstph.ch/fr/staff/profile/people/klaus-reither
Medical Research Programme, Tanzania/LMU Munich, Germany 2005-2006 Study Coordinator. Northern Region Malaria Project, Ghana/Charité Berlin - Other 1993 - 2005 Internal Medicine and Radiology