The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes (Publications)
vaccine formulations, circulating Tfh cells were expanded in Tanzanian volunteers when an experimental malaria vaccine was adjuvanted in GLA-SE but not when formulated in Alum. The GLA-SE-formulated peptide was
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development
Status of insecticide resistance in Papua New Guinea: an update from nation-wide monitoring of anopheles mosquitoes (Publications)
distribution of insecticide-treated nets. Here, we provide an update on phenotypic IR in four highly malaria-endemic areas of PNG. IR against deltamethrin, lambda-cyhalothrin, and dichlorodiphenyltrichloroethane
Helen Prytherch (People)
https://www.swisstph.ch/fr/staff/profile/people/helen-prytherch
(GIZ), Swiss Agency for Development and Cooperation, World Health Organization and the Roll Back Malaria Partnership.
Klaus Reither (People)
https://www.swisstph.ch/fr/staff/profile/people/klaus-reither
Medical Research Programme, Tanzania/LMU Munich, Germany 2005-2006 Study Coordinator. Northern Region Malaria Project, Ghana/Charité Berlin - Other 1993 - 2005 Internal Medicine and Radiology
Monica Golumbeanu (People)
https://www.swisstph.ch/fr/staff/profile/people/monica-golumbeanu
her research focuses on developing data-driven computational analyses and mathematical models of malaria infection dynamics to assess the impact of interventions on host and parasite populations. Previously
A Programmatic Analysis of integrated Community Case Management (iCCM): A Multicountry Systems-Wide Analysis of the RAcE (Rapid Access Expansion) iCCM... (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/a-programmatic-analysis-of-integrated-community-case-management-iccm-a-multicountry-systems-wide-analysis-of-the-race-rapid-access-expansion-iccm-programme-in-sub-saharan-africa
provide children living in remote areas with access to case management for pneumonia, diarrhea, and malaria at the community level. The Rapid Access Expansion Programme (RAcE), steered by the World Health
Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of
Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its... (Publications)
BACKGROUND: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3
Expression of the MSPDBL2 antigen in a discrete subset of <em>Plasmodium falciparum</em> schizonts is regulated by GDV1 but may not be linked to... (Publications)
requires further investigation in natural infections where it is under immune selection. IMPORTANCE: Malaria parasites in the blood are remarkably variable, able to switch antigenic targets so they may survive [...] developed specific immune responses. This is one of the challenges in developing vaccines against malaria. MSPDBL2 is a target of naturally acquired immunity expressed in minority proportions of schizonts