Comparison of cone bioassay estimates at two laboratories with different <em>Anopheles </em>mosquitoes for quality assurance of pyrethroid... (Publications)
insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of
Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols (Publications)
suffer from painful application, severe side effects and increasing resistance against these drugs. Malaria tropica kills more than 2 million people every year mainly due to growing drug resistance. 4-Dia
Mosquito nets and the poor: can social marketing redress inequities in access? (Publications)
Treated mosquito nets are a practical malaria control tool. However, implementation of efficient delivery mechanisms remains a challenge. We investigated whether social marketing of treated mosquito nets
Estimation of infection and recovery rates for highly polymorphic parasites when detectability is imperfect, using hidden Markov models (Publications)
implemented using Markov chain Monte Carlo simulation. The model is applied to a panel data set of malaria genotype data from a randomized controlled trial of bed nets in Tanzanian children aged 6-30 months
Genesis of and trafficking to the Maurer's clefts of <em>Plasmodium falciparum</em>-infected erythrocytes (Publications)
Malaria parasites export proteins beyond their own plasma membrane to locations in the red blood cells in which they reside. Maurer's clefts are parasite-derived structures within the host cell cytoplasm
Complete structural assignment of serratol, a cembrane-type diterpene from <em>Boswellia serrata</em>, and evaluation of its antiprotozoal activity (Publications)
T. cruzi (Chagas' disease), Leishmania donovani (Kala-Azar), and Plasmodium falciparum (Tropical Malaria). It was found active against T. brucei and P. falciparum. These activities were 10- to 15-fold higher
Genetic analysis of IgG subclass responses against RESA and MSP2 of <em>Plasmodium falciparum</em> in adults in Papua New Guinea (Publications)
complex than governed by a single major gene. Such host genetic variation in responses to specific malaria antigens has implications for immuno-epidemiology and vaccine development
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
rapid increase of resistance to drugs commonly used in the treatment of tropical diseases such as malaria and African sleeping sickness calls for the prompt development of new safe and efficacious drugs
New amidated 3,6-diphenylated imidazopyridazines with potent antiplasmodium activity are dual inhibitors of <em>Plasmodium... (Publications)
idazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities (Publications)
An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested