Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)
subsequent febrile malaria or with an increased risk. CONCLUSIONS: The number of clones in asymptomatic P. falciparum infections is associated with different risks of subsequent clinical malaria depending on [...] BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in [...] in asymptomatic P. falciparum infections affects the subsequent risk of...
Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of... (Publications)
of existing malaria interventions is becoming increasingly important as evidence mounts that progress on reducing malaria incidence is stalling and threatened by resistance. METHODS: Malaria transmission [...] on and intervention dynamics were simulated using OpenMalaria, an individual-based simulation model of malaria transmission, by considering a seasonal transmission setting and by varying epidemiological [...] of seasonal mass applications of preventative anti-infective malaria vaccines,...
The <em>Plasmodium falciparum</em> Hsp70-x chaperone assists the heat stress response of the malaria parasite (Publications)
Plasmodium falciparum is the most lethal of human-infective malaria parasites. A hallmark of P. falciparum malaria is extensive remodeling of host erythrocytes by the parasite, which facilitates the d [...] Vakonakis, I. The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.
Mapping routine malaria incidence at village level for targeted control in Papua New Guinea (Publications)
Malaria surveillance and response-systems are essential for identifying the areas most affected by malaria and for targeting interventions and optimising resources. This study aimed to assess whether the
Differential impact of malaria control interventions on <em>P. falciparum</em> and <em>P. vivax</em> infections in young Papua New Guinean children (Publications)
children and the key risk factors for malaria infection and illness in 2013. RESULTS: Between 2006 and 2008, P. falciparum infection prevalence, molFOB, and clinical malaria episodes reduced by 47%, 59% and [...] INTRODUCTION: As malaria transmission declines, understanding the differential impact of intensified control on Plasmodium falciparum relative to Plasmodium vivax and identifying key drivers of ongoing [...] cohort, children aged 1-5 years were actively monitored for infection and...
Investigating the drivers of the spatio-temporal patterns of genetic differences between <em>Plasmodium falciparum</em> malaria infections in Kilifi... (Publications)
Knowledge of how malaria infections spread locally is important both for the design of targeted interventions aiming to interrupt malaria transmission and the design of trials to assess the interventions [...] to account for the observed patterns. The mean geographic distance between parent and offspring malaria infections for the base model was 0.5 km (95% CI 0.3-1.5), for a distribution with 68% of distances
The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)
diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are [...] This study demonstrates the successful use of a self-marking device in an MMRR study with African malaria vectors. This method may be useful in investigating population structure and dispersal of mosquitoes
Malaria: «Einstein» und die Spritze der Hoffnung (Publications)
In Afrika läuft die weltweit erste Impfkampagne gegen Malaria. In Ghana, Malawi und Kenia werden bis 2022 gegen zwei Millionen Kleinkinder mit dem Vakzin «RTS’S» geimpft. «Einstein» hat die Entwicklung [...] begleitet. Die Langzeit-Dokumentation zeigt auf, wie schwierig der Weg zur ersehnten neuen Waffe gegen Malaria war. Die Schweiz spielte bei der Entwicklung des Impfstoffs eine tragende Rolle, doch die Testreihen [...] und echte Forschungspartnerschaft zwischen Nord und Süd möglich war. Die...
Sex: how malaria parasites get turned on (Publications)
initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.
